UM  > 健康科學學院
Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis
Wang X.1,2; Kimbrel E.A.3; Ijichi K.4; Paul D.5; Lazorchak A.S.2; Chu J.3; Kouris N.A.3; Yavanian G.J.3; Lu S.-J.3; Pachter J.S.5; Crocker S.J.4; Lanza R.3; Xu R.-H.1,2,6
2014-07-08
Source PublicationStem Cell Reports
ISSN22136711
Volume3Issue:1Pages:115-130
Abstract

Current therapies for multiple sclerosis (MS) are largely palliative, not curative. Mesenchymal stem cells (MSCs) harbor regenerative and immunosuppressive functions, indicating a potential therapy for MS, yet the variability and low potency of MSCs from adult sources hinder their therapeutic potential. MSCs derived from human embryonic stem cells (hES-MSCs) may be better suited for clinical treatment of MS because of their unlimited and stable supply. Here, we show that hES-MSCs significantly reduce clinical symptoms and prevent neuronal demyelination in a mouse experimental autoimmune encephalitis (EAE) model of MS, and that the EAE disease-modifying effect of hES-MSCs is significantly greater than that of human bone-marrow-derived MSCs (BM-MSCs). Our evidence also suggests that increased IL-6 expression by BM-MSCs contributes to the reduced anti-EAE therapeutic activity of these cells. A distinct ability to extravasate and migrate into inflamed CNS tissues may also be associated with the robust therapeutic effects of hES-MSCs on EAE. 

DOIhttps://doi.org/10.1016/j.stemcr.2014.04.020
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology
WOS SubjectCell & Tissue Engineering ; Cell Biology
WOS IDWOS:000340882100013
PublisherCELL PRESS, 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:73   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLanza R.; Xu R.-H.
Affiliation1.Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
2.ImStem Biotechnology, Inc., 400 Farmington Avenue, Farmington, CT 06030, USA
3.Advanced Cell Technology, 33 Locke Drive, Marlborough, MA 01752, USA
4.Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
5.Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
6.Faculty of Health Sciences, University of Macau, Taipa, Macau, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Wang X.,Kimbrel E.A.,Ijichi K.,et al. Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis[J]. Stem Cell Reports,2014,3(1):115-130.
APA Wang X..,Kimbrel E.A..,Ijichi K..,Paul D..,Lazorchak A.S..,...&Xu R.-H..(2014).Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis.Stem Cell Reports,3(1),115-130.
MLA Wang X.,et al."Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis".Stem Cell Reports 3.1(2014):115-130.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang X.]'s Articles
[Kimbrel E.A.]'s Articles
[Ijichi K.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang X.]'s Articles
[Kimbrel E.A.]'s Articles
[Ijichi K.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang X.]'s Articles
[Kimbrel E.A.]'s Articles
[Ijichi K.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.