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Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS
Gao J.L.1; Leung K.S.Y.2; Wang Y.T.1; Lai C.M.1; Li S.P.1; Hu L.F.1; Lu G.H.3; Jiang Z.H.3; Yu Z.L.3
2007
Source PublicationJournal of Pharmaceutical and Biomedical Analysis
ISSN7317085
Volume44Issue:3 SPEC. ISS.Pages:807
Abstract

A high-performance liquid chromatography-diode array detector-mass spectrometry (HPLC-DAD-MS) analytical method was developed for detection of the nucleosides and nucleobases in two species of Lingzhi, the dried sporophore of Ganoderma lucidum and G. sinense. The method, combining advantages of both DAD and MS, was successfully used to qualitatively identify for six nucleosides namely, adenosine, cytidine, guanosine, inosine, thymidine, uridine and five nucleobases namely, adenine, guanine, hypoxanthine, thymine and uracil in Lingzhi samples. Quantitative analyses showed that uridine was the most abundant nucleoside in these Lingzhi samples and the contents of nine target analytes were found to be different in pileus and stipes of the fruiting bodies and among the different species of G. spp. The established method might apply as an alternative approach for the quality assessment of Lingzhi. © 2007 Elsevier B.V. All rights reserved.

KeywordG. Sinense Ganoderma Lucidum Hplc-dad-ms Nucleobase Nucleoside Quantitative Analysis
DOIhttp://doi.org/10.1016/j.jpba.2007.03.012
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS IDWOS:000248738200024
The Source to ArticleScopus
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Cited Times [WOS]:57   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYu Z.L.
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
3.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Gao J.L.,Leung K.S.Y.,Wang Y.T.,et al. Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS[J]. Journal of Pharmaceutical and Biomedical Analysis,2007,44(3 SPEC. ISS.):807.
APA Gao J.L..,Leung K.S.Y..,Wang Y.T..,Lai C.M..,Li S.P..,...&Yu Z.L..(2007).Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS.Journal of Pharmaceutical and Biomedical Analysis,44(3 SPEC. ISS.),807.
MLA Gao J.L.,et al."Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS".Journal of Pharmaceutical and Biomedical Analysis 44.3 SPEC. ISS.(2007):807.
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