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Fabrication of graphene-isolated-au-nanocrystal nanostructures for multimodal cell imaging and photothermal-enhanced chemotherapy
Bian X.1; Song Z.-L.1; Qian Y.1; Gao W.1; Cheng Z.-Q.1; Chen L.2; Liang H.1; Ding D.1; Nie X.-K.1; Chen Z.1; Tan W.1,3,4,5
2014
Source PublicationScientific Reports
ISSN20452322
Volume4
Abstract

Using nanomaterials to develop multimodal systems has generated cutting-edge biomedical functions. Herein, we develop a simple chemical-vapor-deposition method to fabricate graphene-isolated-Au-nanocrystal (GIAN) nanostructures. A thin layer of graphene is precisely deposited on the surfaces of gold nanocrystals to enable unique capabilities. First, as surface-enhanced-Raman-scattering substrates, GIANs quench background fluorescence and reduce photocarbonization or photobleaching of analytes. Second, GIANs can be used for multimodal cell imaging by both Raman scattering and near-infrared (NIR) two-photon luminescence. Third, GIANs provide a platform for loading anticancer drugs such as doxorubicin (DOX) for therapy. Finally, their NIR absorption properties give GIANs photothermal therapeutic capability in combination with chemotherapy. Controlled release of DOX molecules from GIANs is achieved through NIR heating, significantly reducing the possibility of side effects in chemotherapy. The GIANs have high surface areas and stable thin shells, as well as unique optical and photothermal properties, making them promising nanostructures for biomedical applications.

DOI10.1038/srep06093
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000341441800001
The Source to ArticleScopus
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Cited Times [WOS]:69   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF COMPUTER AND INFORMATION SCIENCE
Affiliation1.Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Collaborat Innovat Ctr Chem & Mol Med, Coll Chem & Chem Engn,Coll Biol,Mol Sci & Biomed, Changsha 410082, Hunan, Peoples R China
2.Univ Macau, Fac Sci, Macau, Peoples R China
3.Univ Florida, Dept Chem, Gainesville, FL 32611 USA
4.Univ Florida, Dept Physiol & Funct Genom, Ctr Res Bio Nano Interface, Shands Canc Ctr,UF Genet Inst, Gainesville, FL 32611 USA
5.Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA
Recommended Citation
GB/T 7714
Bian X.,Song Z.-L.,Qian Y.,et al. Fabrication of graphene-isolated-au-nanocrystal nanostructures for multimodal cell imaging and photothermal-enhanced chemotherapy[J]. Scientific Reports,2014,4.
APA Bian X..,Song Z.-L..,Qian Y..,Gao W..,Cheng Z.-Q..,...&Tan W..(2014).Fabrication of graphene-isolated-au-nanocrystal nanostructures for multimodal cell imaging and photothermal-enhanced chemotherapy.Scientific Reports,4.
MLA Bian X.,et al."Fabrication of graphene-isolated-au-nanocrystal nanostructures for multimodal cell imaging and photothermal-enhanced chemotherapy".Scientific Reports 4(2014).
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