UM
Polymeric Nanomedicine with "Lego" Surface Allowing Modular Functionalization and Drug Encapsulation
Sun, Chen; Zhang, Haipeng; Li, Shengke; Zhang, Xiangjun; Cheng, Qian; Ding, Yuanfu; Wang, Lian-Hui; Wang, Ruibing
2018-08
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:30Pages:25090-25098
AbstractSurface functionalization of nanoparticles (NPs) is of pivotal importance in nanomedicine. However, current strategies often require covalent conjugation that involves laborious design and synthesis. Herein, cucurbit[7]uril (CB[7])-decorated poly(lactic acid) (PLA)/poly(lacticco-glycolic acid) (PLGA) NPs are developed and exploited for the first time as a novel, biocompatible, and versatile drug delivery platform with a noncovalently tailorable surface. CB[7] on the surface of NPs, acting as a "Lego" base block, allowed facile, modular surface modification with a variety of functional moieties or tags that are linked with amantadine (a complementary "Lego" piece to the base block), including amantadine-conjugated folate, polyethylene glycol, and fluorescein isothiocyanate. In addition, surface CB[7] also provided an opportunity for encapsulation of a secondary drug, such as oxaliplatin, into the cavity of the base block CB[7], in addition to a primary drug (e.g., paclitaxel) loaded into PLA/ PLGA NPs, for a possible synergistic chemotherapy. This proof of concept not only provides the first versatile PLA/PLGA nanomedicine platform with "Lego" surface for modular functionalization and improved drug delivery but also offers new insights into the design and development of novel nanomedicine with a modular surface.
Keywordcucurbituril surface functionalization nanomedicine PLA/PLGA drug delivery
DOI10.1021/acsami.8b06598
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000440956000017
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Sun, Chen,Zhang, Haipeng,Li, Shengke,et al. Polymeric Nanomedicine with "Lego" Surface Allowing Modular Functionalization and Drug Encapsulation[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(30):25090-25098.
APA Sun, Chen.,Zhang, Haipeng.,Li, Shengke.,Zhang, Xiangjun.,Cheng, Qian.,...&Wang, Ruibing.(2018).Polymeric Nanomedicine with "Lego" Surface Allowing Modular Functionalization and Drug Encapsulation.ACS APPLIED MATERIALS & INTERFACES,10(30),25090-25098.
MLA Sun, Chen,et al."Polymeric Nanomedicine with "Lego" Surface Allowing Modular Functionalization and Drug Encapsulation".ACS APPLIED MATERIALS & INTERFACES 10.30(2018):25090-25098.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sun, Chen]'s Articles
[Zhang, Haipeng]'s Articles
[Li, Shengke]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sun, Chen]'s Articles
[Zhang, Haipeng]'s Articles
[Li, Shengke]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sun, Chen]'s Articles
[Zhang, Haipeng]'s Articles
[Li, Shengke]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.