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Intraoperative Detection and Eradication of Residual Microtumors with Gap-Enhanced Raman Tags
Qiu, Yuanyuan1; Zhang, Yuqing2; Li, Mingwang1; Chen, Gaoxian1; Fan, Chenchen1; Cui, Kai1; Wan, Jian-Bo3; Han, Anpan4; Ye, Jian2; Xiao, Zeyu5
2018-08
Source PublicationACS NANO
ISSN1936-0851
Volume12Issue:8Pages:7974-7985
Abstract

The inability to intraoperatively diagnose and eliminate microscopic residual tumors represents a significant challenge in cancer surgery. These residual microtumors cause lethal recurrence and metastasis. Herein, we show a crucial example of Raman imaging with gap-enhanced Raman tags (GERTs) to serve as a robust platform for intraoperative detection and eradication of residual microscopic foci, which exist in surgical margins, tumor invasion, and multifocal tumor spread. The GERTs feature gap-enhanced gold core-shell nanostructures, with Raman reporters embedding inside the interior gap junction. This nanostructure elicits highly sensitive and photostable Raman signals for microtumor detection by applying a 785 nm, low-energy laser and produces hyperthermia effects for microtumor ablation upon switching a 808 nm, high-power laser. In the orthotopic prostate metastasis tumor model, systematic delivery of GERTs enabled precise imaging and real-time ablation of macroscopic malignant lesions around the surgical bed without damaging normal tissues. Consequently, the GERTs-based surgery prevented local recurrence and delivered 100% tumor-free survival. These results suggest the efficiency of theranostic GERTs for precise detection and removal of residual miroctumors, broadening the avenues to apply Raman-based imaging for theranostic precision medicine.

KeywordNanomedicine Gap-enhanced Raman Tag Cancer Theranostics Residual Microtumors Surface-enhanced Raman Spectroscopy
DOI10.1021/acsnano.8b02681
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000443525600049
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:24   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYe, Jian; Xiao, Zeyu
Affiliation1.Department of Pharmacology and Chemical Biology, Translational Medicine Collaborative Innovation Center, Institute of Medical Sciences, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, P.R. China
2.State Key Laboratory of Oncogenes and Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P.R. China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao China
4.DTU Danchip/CEN, Technical University of Denmark, Kgs. Lyngby 2800, Denmark
5.Department of Pharmacology and Chemical Biology, Translational Medicine Collaborative Innovation Center, Institute of Medical Sciences, School of Medicine, Institute of Molecular Medicine, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, P.R. China
Recommended Citation
GB/T 7714
Qiu, Yuanyuan,Zhang, Yuqing,Li, Mingwang,et al. Intraoperative Detection and Eradication of Residual Microtumors with Gap-Enhanced Raman Tags[J]. ACS NANO,2018,12(8):7974-7985.
APA Qiu, Yuanyuan.,Zhang, Yuqing.,Li, Mingwang.,Chen, Gaoxian.,Fan, Chenchen.,...&Xiao, Zeyu.(2018).Intraoperative Detection and Eradication of Residual Microtumors with Gap-Enhanced Raman Tags.ACS NANO,12(8),7974-7985.
MLA Qiu, Yuanyuan,et al."Intraoperative Detection and Eradication of Residual Microtumors with Gap-Enhanced Raman Tags".ACS NANO 12.8(2018):7974-7985.
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