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Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice
Seto S.W.; Lam T.Y.; Tam H.L.; Au A.L.S.; Chan S.W.; Wu J.H.; Yu P.H.F.; Leung G.P.H.; Ngai S.M.; Yeung J.H.K.; Leung P.S.; Lee S.M.Y.; Kwan Y.W.
2009
Source PublicationPhytomedicine
ISSN9447113
Volume16Issue:5Pages:426
AbstractIn this study, we evaluated the pharmacological effects of Ganoderma lucidum (G. lucidum) (water-extract) (0.003, 0.03 and 0.3 g/kg, 4-week oral gavage) consumption using the lean (+db/+m) and the obese/diabetic (+db/+db) mice. Different physiological parameters (plasma glucose and insulin levels, lipoproteins-cholesterol levels, phosphoenolpyruvate carboxykinase (PEPCK), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) and isolated aorta relaxation of both species were measured and compared. G. lucidum (0.03 and 0.3 g/kg) lowered the serum glucose level in +db/+db mice after the first week of treatment whereas a reduction was observed in +db/+m mice only fed with 0.3 g/kg of G. lucidum at the fourth week. A higher hepatic PEPCK gene expression was found in +db/+db mice. G. lucidum (0.03 and 0.3 g/kg) markedly reduced the PEPCK expression in +db/+db mice whereas the expression of PEPCK was attenuated in +db/+m mice (0.3 g/kg G. lucidum). HMG CoA reductase protein expression (in both hepatic and extra-hepatic organs) and the serum insulin level were not altered by G. lucidum. These data demonstrate that G. lucidum consumption can provide beneficial effects in treating type 2 diabetes mellitus (T2DM) by lowering the serum glucose levels through the suppression of the hepatic PEPCK gene expression. © 2008 Elsevier GmbH. All rights reserved.
KeywordGanoderma lucidum HMG CoA reductase PEPCK Type 2 diabetes mellitus
DOI10.1016/j.phymed.2008.10.004
URLView the original
Language英语
The Source to ArticleScopus
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Cited Times [WOS]:68   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Seto S.W.,Lam T.Y.,Tam H.L.,et al. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice[J]. Phytomedicine,2009,16(5):426.
APA Seto S.W..,Lam T.Y..,Tam H.L..,Au A.L.S..,Chan S.W..,...&Kwan Y.W..(2009).Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.Phytomedicine,16(5),426.
MLA Seto S.W.,et al."Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice".Phytomedicine 16.5(2009):426.
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