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Quantification and separation of protopanaxatriol and protopanaxadiol type saponins from Panax notoginseng with macroporous resins
Wan J.B.1; Zhang Q.W.1; Ye W.C.2; Wang Y.T.1
2008
Source PublicationSeparation and Purification Technology
ISSN13835866
Volume60Issue:2Pages:198
Abstract

20(S)-protopanaxatriol saponins (PTS) and 20(S)-protopanaxadiol saponins (PDS) are known as two groups of major ingredients in the root of Panax notoginseng and possess various pharmacological effects. In the present study, a simple method for preparative separation of PTS and PDS from P. notoginseng with macroporous resins was established. The adsorption characteristics of PTS and PDS on four types of macroporous resins, including D-101, DA-201, DM-301 and DS-401, have been compared. Among them, DS-401 resin showed the best separation behaviors. The equilibrium absorption data of PTS and PDS on DS-401 resin at 25oC was fitted to the Freundlich isotherm. Dynamic adsorption and desorption tests have been performed in glass column packed with DS-401 resin for optimizing the process parameters. Due to different adsorption force to resin, the PTS and PDS were successfully separated with 30% and 80% (v/v) aqueous ethanol solutions, respectively. Based on the conditions optimized above, large-scale preparation of PTS and PDS from P. notoginseng was also carried out. The contents of PTS and PDS were increased from 22.5% and 16.4% in the PLE extract of the root of P. notoginseng to 88.2% and 92.6% in the final products with the recoveries of 80.2% and 82.3%, respectively. © 2007 Elsevier B.V. All rights reserved.

Keyword20(s)-protopanaxadiol 20(s)-protopanaxatriol Macroporous Resins Panax Notoginseng Pressurized Liquid Extraction
DOIhttp://doi.org/10.1016/j.seppur.2007.08.007
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
WOS IDWOS:000255468800012
The Source to ArticleScopus
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Cited Times [WOS]:71   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang Q.W.; Wang Y.T.
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
2.Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, PR China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wan J.B.,Zhang Q.W.,Ye W.C.,et al. Quantification and separation of protopanaxatriol and protopanaxadiol type saponins from Panax notoginseng with macroporous resins[J]. Separation and Purification Technology,2008,60(2):198.
APA Wan J.B.,Zhang Q.W.,Ye W.C.,&Wang Y.T..(2008).Quantification and separation of protopanaxatriol and protopanaxadiol type saponins from Panax notoginseng with macroporous resins.Separation and Purification Technology,60(2),198.
MLA Wan J.B.,et al."Quantification and separation of protopanaxatriol and protopanaxadiol type saponins from Panax notoginseng with macroporous resins".Separation and Purification Technology 60.2(2008):198.
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