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Antibacterial activity of two-dimensional MoS2 sheets
Yang X.1; Li J.2; Liang T.1; Ma C.1; Zhang Y.1; Chen H.1; Hanagata N.2; Su H.3; Xu M.1
Source PublicationNanoscale

Graphene-like two-dimensional materials (2DMats) show application potential in optoelectronics and biomedicine due to their unique properties. However, environmental and biological influences of these 2DMats remain to be unveiled. Here we reported the antibacterial activity of two-dimensional (2D) chemically exfoliated MoS2 (ce-MoS2) sheets. We found that the antibacterial activity of ce-MoS2 sheets was much more potent than that of the raw MoS2 powders used for the synthesis of ce-MoS 2 sheets possibly due to the 2D planar structure (high specific surface area) and higher conductivity of the ce-MoS2. We investigated the antibacterial mechanisms of the ce-MoS2 sheets and proposed their antibacterial pathways. We found that the ce-MoS2 sheets could produce reactive oxygen species (ROS), different from a previous report on graphene-based materials. Particularly, the oxidation capacity of the ce-MoS2 sheets toward glutathione oxidation showed a time and concentration dependent trend, which is fully consistent with the antibacterial behaviour of the ce-MoS2 sheets. The results suggest that antimicrobial behaviors were attributable to both membrane and oxidation stress. The antibacterial pathways include MoS2-bacteria contact induced membrane stress, superoxide anion (O2 -) induced ROS production by the ce-MoS2, and the ensuing superoxide anion-independent oxidation. Our study thus indicates that the tailoring of the dimension of nanomaterials and their electronic properties would manipulate antibacterial activity. © 2014 the Partner Organisations.

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Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000340520500031
The Source to ArticleScopus
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Cited Times [WOS]:108   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen H.; Hanagata N.; Su H.; Xu M.
Affiliation1.State Key Laboratory of Silicon Materials, MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China
2.Interdisciplinary Laboratory for Nanoscale Science and Technology, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Japan
3.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau SAR, P. R. China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yang X.,Li J.,Liang T.,et al. Antibacterial activity of two-dimensional MoS2 sheets[J]. Nanoscale,2014,6(17):10126.
APA Yang X..,Li J..,Liang T..,Ma C..,Zhang Y..,...&Xu M..(2014).Antibacterial activity of two-dimensional MoS2 sheets.Nanoscale,6(17),10126.
MLA Yang X.,et al."Antibacterial activity of two-dimensional MoS2 sheets".Nanoscale 6.17(2014):10126.
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