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The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review
Chen X.; Guo J.; Bao J.; Lu J.; Wang Y.
2014
Source PublicationMedicinal Research Reviews
ISSN1986325
Volume34Issue:4Pages:768
Abstract

Salvia miltiorrhiza Bunge (Danshen in Chinese) is a classical Huoxue Huayu (a traditional Chinese medical term means promoting blood circulation and removing blood stasis) herb with 1000 years of clinical application. It mainly contains two groups of ingredients: the hydrophilic phenolic acids and the lipophilic tanshinones. Both groups have demonstrated multiple bioactivities, such as antioxidative stress, antiplatelet aggregation, anti-inflammation, among others. Recent data have demonstrated that its lipophilic compounds, especially the tanshinones, show potent anticancer activities both in vitro and in vivo. The anticancer effects of the hydrophilic phenolic acids have also been reported. Furthermore, tanshinones provide structural skeletons for chemical modifications, allowing for a series of derivatives of interests. This review provides a systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones, aiming to bring new insights for further research and development of this ancient herb. © 2013 Wiley Periodicals, Inc.

KeywordCancer Derivatives Phenolic Acids Salvia Miltiorrhiza Bunge Tanshinones
DOIhttp://doi.org/10.1002/med.21304
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000337677100004
The Source to ArticleScopus
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Cited Times [WOS]:104   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen X.
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen X.,Guo J.,Bao J.,et al. The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review[J]. Medicinal Research Reviews,2014,34(4):768.
APA Chen X.,Guo J.,Bao J.,Lu J.,&Wang Y..(2014).The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review.Medicinal Research Reviews,34(4),768.
MLA Chen X.,et al."The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review".Medicinal Research Reviews 34.4(2014):768.
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