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Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment
Liu J.1; Yang Y.2; Zhu W.1; Yi X.3; Dong Z.1; Xu X.1; Chen M.2; Yang K.3; Lu G.1; Jiang L.4; Liu Z.1
2016
Source PublicationBiomaterials
ISSN1429612
Volume97Pages:1
Abstract

Nanoscale metal organic frameworks (NMOFs) have shown great potential in biomedicine owing to their structural/chemical diversities, high molecular loading capacities, and intrinsic biodegradability. Herein, we report the rational design of a NMOF composed by hafnium (Hf4+) and tetrakis (4-carboxyphenyl) porphyrin (TCPP). In such Hf-TCPP NMOFs, while TCPP is a photosensitizer to allow photodynamic therapy (PDT), Hf4+ with strong X-ray attenuation ability could serve as a radio-sensitizer to enhance radiotherapy (RT). Those NMOFs with polyethylene glycol (PEG) coating show efficient tumor homing upon intravenous injection, and thus could be used for in vivo combined RT & PDT, achieving a remarkable anti-tumor effect. Importantly, Hf-TCPP NMOFs show efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity. Our work thus presents a new concept of developing multifunctional NMOFs as a biodegradable carrier-free system, in which both metal ions and organic ligands are fully utilized to exert their therapeutic functions. © 2016 Elsevier Ltd.

KeywordCombination Therapy Nanoscale Metal-organic Framework Photodynamic Therapy Radiation Therapy
DOI10.1016/j.biomaterials.2016.04.034
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000377735800001
The Source to ArticleScopus
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Cited Times [WOS]:131   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidad, Taipa, Macau, China
3.School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu, 215123, China
4.Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated, No.6 Hospital Yishan Road 600, Shanghai, 200233, China
Recommended Citation
GB/T 7714
Liu J.,Yang Y.,Zhu W.,et al. Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment[J]. Biomaterials,2016,97:1.
APA Liu J..,Yang Y..,Zhu W..,Yi X..,Dong Z..,...&Liu Z..(2016).Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment.Biomaterials,97,1.
MLA Liu J.,et al."Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment".Biomaterials 97(2016):1.
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