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Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe
He H.-Z.1; Leung K.-H.1; Wang W.1; Chan D.S.-H.1; Leung C.-H.2; Ma D.-L.1
2014
Source PublicationChemical Communications
ISSN13597345
Volume50Issue:40Pages:5313
Abstract

A label-free, oligonucleotide-based, switch-on luminescence detection method for T4 polynucleotide kinase activity has been developed using a novel G-quadruplex-selective luminescent Ir(III) complex probe. The application of the assay for screening potential T4 PNK inhibitors is also demonstrated. To our knowledge, this is the first metal-based assay for PNK activity. © the Partner Organisations 2014.

DOI10.1039/c3cc47444e
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000335011200047
The Source to ArticleScopus
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Cited Times [WOS]:108   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa D.-L.
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation
GB/T 7714
He H.-Z.,Leung K.-H.,Wang W.,et al. Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe[J]. Chemical Communications,2014,50(40):5313.
APA He H.-Z.,Leung K.-H.,Wang W.,Chan D.S.-H.,Leung C.-H.,&Ma D.-L..(2014).Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe.Chemical Communications,50(40),5313.
MLA He H.-Z.,et al."Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe".Chemical Communications 50.40(2014):5313.
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