UM  > 中華醫藥研究院
Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability
Sun J.1,2; Bi C.1; Chan H.M.1; Sun S.3; Zhang Q.1; Zheng Y.1
2013
Source PublicationColloids and Surfaces B: Biointerfaces
ISSN9277765
Volume111Pages:367
Abstract

Purpose: The aim of the present study was to blend liquid lipids with solid lipids to encapsulate curcumin in solid lipid nanoparticles (SLNs), thereby improving the dispersibility and chemical stability of curcumin, prolonging its antitumour activity and cellular uptake and enhancing its bioavailability. Methods: Curcumin-loaded SLNs (C-SLNs) were prepared by high-pressure homogenisation with liquid lipid Sefsol-218®. The morphology, stability and release of curcumin in the optimised formulation were investigated. The anti-cancer activity of the formulation was evaluated in MCF-7 cells. Fluorescence spectrophotometry was used to quantify cellular uptake of the drug. The pharmacokinetic profiles of curcumin in SLNs after intravenous administration were studied in rats. Results: Blending Sefsol-218® into a lipid matrix reduced the particle size without improving drug loading. An optimised formulation consisting of Dynasan 114®, Sefsol-218®, and Pluronic F68® (630:70:300, w/w) loaded with 0.8% drug was prepared. This formulation could be dispersed in water with a mean particle size of 152.8±4.7nm and a 90% entrapment efficiency. Curcumin displayed a two-phase sustained release profile from C-SLNs with improved chemical stability. Compared to the solubilised solution, C-SLNs exhibited prolonged inhibitory activity in cancer cells, as well as time-dependent increases in intracellular uptake. After intravenous administration to rats, the bioavailability of curcumin was increased by 1.25-fold. Conclusions: C-SLNs with improved dispersibility and chemical stability in an aqueous system have been successfully developed. C-SLNs may represent a potentially useful cancer therapeutic curcumin delivery system. © 2013 Elsevier B.V.

KeywordBioavailability Cellular Uptake Curcumin Sefsol-218® Solid Lipid Nanoparticles (Slns) Stability
DOI10.1016/j.colsurfb.2013.06.032
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiophysics ; Chemistry ; Materials Science
WOS SubjectBiophysics ; Chemistry, Physical ; Materials Science, bioMaterials
WOS IDWOS:000324897900048
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:112   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
2.National Institute for Food and Drug Control, Beijing, China
3.School of Chemistry & Chemical Engineering & Materials Science, Heilongjiang University, Harbin, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Sun J.,Bi C.,Chan H.M.,et al. Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability[J]. Colloids and Surfaces B: Biointerfaces,2013,111:367.
APA Sun J.,Bi C.,Chan H.M.,Sun S.,Zhang Q.,&Zheng Y..(2013).Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability.Colloids and Surfaces B: Biointerfaces,111,367.
MLA Sun J.,et al."Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability".Colloids and Surfaces B: Biointerfaces 111(2013):367.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sun J.]'s Articles
[Bi C.]'s Articles
[Chan H.M.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sun J.]'s Articles
[Bi C.]'s Articles
[Chan H.M.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sun J.]'s Articles
[Bi C.]'s Articles
[Chan H.M.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.