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A metal-based inhibitor of tumor necrosis factor-α
Leung C.-H.1,2; Zhong H.-J.1,2; Yang H.3; Cheng Z.3; Chan D.S.-H.3; Ma V.P.-Y.3; Abagyan R.4; Wong C.-Y.5; Ma D.-L.3
2012
Source PublicationAngewandte Chemie - International Edition
ISSN14337851
Volume51Issue:36Pages:9010
Abstract

Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KeywordInhibitors Iridium(Iii) Complexes Metal-based Inhibitors Protein-protein Interactions Tumor Necrosis Factor
DOI10.1002/anie.201202937
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000308043900008
The Source to ArticleScopus
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Cited Times [WOS]:134   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Univ Macau, Inst Chinese Med Sci, Macao, Peoples R China
2.Univ Macau, State Key Lab Qual Res Chinese Med, Macao, Peoples R China
3.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
4.Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, San Diego, CA 92103 USA
5.City Univ Hong Kong, Dept Biol & Chem, Kowloon Tong, Hong Kong, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Leung C.-H.,Zhong H.-J.,Yang H.,et al. A metal-based inhibitor of tumor necrosis factor-α[J]. Angewandte Chemie - International Edition,2012,51(36):9010.
APA Leung C.-H..,Zhong H.-J..,Yang H..,Cheng Z..,Chan D.S.-H..,...&Ma D.-L..(2012).A metal-based inhibitor of tumor necrosis factor-α.Angewandte Chemie - International Edition,51(36),9010.
MLA Leung C.-H.,et al."A metal-based inhibitor of tumor necrosis factor-α".Angewandte Chemie - International Edition 51.36(2012):9010.
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