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Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies
Zhao Y.1; Wang C.1; Chow A.H.L.2; Ren K.3; Gong T.3; Zhang Z.3; Zheng Y.1
2010-01-04
Source PublicationInternational Journal of Pharmaceutics
ISSN0378-5173
Volume383Issue:1-2Pages:170
Abstract

The aim of the present study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) for the oral delivery of Zedoary turmeric oil (ZTO), an essential oil extracted from the dry rhizome of Curcuma zedoaria. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification regions. ZTO could serve as a partial oil phase with the aid of the second oil phase to enhance drug loading. Increasing the surfactant concentration reduced the droplet size but increased the emulsification time, while the reverse effect was observed by increasing the co-surfactant concentration. Based on the emulsification time, droplet size and zeta potential after dispersion into aqueous phase, an optimized formulation consisting of ZTO, ethyl oleate, Tween 80, transcutol P (30.8:7.7:40.5:21, w/w) and loaded with 30% drug was prepared. Upon mixing with water, the formulation was rapidly dispersed into fine droplets with a mean size of 68.3 ± 1.6 nm and ξ-potential of -41.2 ± 1.3 mV. The active components remained stable in the optimized SNEDDS stored at 25 °C for at least 12 months. Following oral administration of ZTO-SNEDDS in rats, both AUC and Cmax of germacrone (GM), a representative bioactive marker of ZTO, increased by 1.7-fold and 2.5-fold respectively compared with the unformulated ZTO. 

KeywordBioavailability Essential Oil Formulation Pseudo-ternary Phase Diagram Self-nanoemulsifying Zedoary Turmeric Oil
DOIhttps://doi.org/10.1016/j.ijpharm.2009.08.035
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000272809800024
The Source to ArticleScopus
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Cited Times [WOS]:140   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZheng Y.
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira S.J., Taipa, Macao SAR, China
2.School of Pharmacy, The Chinese University of Hong Kong, Hong Kong SAR, China
3.Key Laboratory of Drug Targeting, Ministry of Education, Sichuan University, No. 17, Section 3, Southern Renmin Road, Chengdu 610041, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhao Y.,Wang C.,Chow A.H.L.,et al. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies[J]. International Journal of Pharmaceutics,2010,383(1-2):170.
APA Zhao Y..,Wang C..,Chow A.H.L..,Ren K..,Gong T..,...&Zheng Y..(2010).Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies.International Journal of Pharmaceutics,383(1-2),170.
MLA Zhao Y.,et al."Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies".International Journal of Pharmaceutics 383.1-2(2010):170.
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