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Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities
Xu Z.1,2; Chen X.1; Zhong Z.1; Chen L.2; Wang Y.1
Source PublicationAmerican Journal of Chinese Medicine

Ganoderma lucidum (G. lucidum), a basidiomycete white rot fungus, has long been prescribed to prevent and treat various human diseases, particularly in China, Japan, and Korea. Several classes of bioactive substances have been isolated and identified from G. lucidum, such as triterpenoids, polysaccharides, nucleosides, sterols, and alkaloids, among others. This paper examines the potential role of G. lucidum polysaccharide (GLPS) in tumor therapy and the possible mechanisms involved. Both in vitro and in vivo studies suggested that the anti-tumor activities of GLPS are mediated by its immunomodulatory, anti-angiogenic, and cytotoxic effects. GLPS affects immune cells and immune-related cells including B lymphocytes, T lymphocytes, dendritic cells, macrophages, and natural killer cells. In addition, recent data also suggest that GLPS suppresses tumorigenesis or inhibits tumor growth through direct cytotoxic effect and anti-angiogenic actions. However, many questions still need to be answered before both G. lucidum and GLPS can be widely accepted and used as anti-tumor agents. © 2011 World Scientific Publishing Company & Institute for Advanced Research in Asian Science and Medicine.

KeywordAnti-angiogenesis Anti-proliferation Ganoderma Lucidum Immunomodulation Polysaccharides
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Indexed BySCI
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000287004800002
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Cited Times [WOS]:144   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Medical Sciences University of Macau, Macau, P. R. China
2.Department of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou, P. R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xu Z.,Chen X.,Zhong Z.,et al. Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities[J]. American Journal of Chinese Medicine,2011,39(1):15.
APA Xu Z.,Chen X.,Zhong Z.,Chen L.,&Wang Y..(2011).Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities.American Journal of Chinese Medicine,39(1),15.
MLA Xu Z.,et al."Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities".American Journal of Chinese Medicine 39.1(2011):15.
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