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UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids
He, Junbin1; Chen, Kuan1; Hu, Zhi-min1; Li, Kai1; Song, Wei1; Yu, Li-yan2,3; Leung, Chung-Hang4; Ma, Dik-Lung5; Qiao, Xue1; Ye, Min1
2018-08-11
Source PublicationCHEMICAL COMMUNICATIONS
ISSN1359-7345
Volume54Issue:62Pages:8594-8597
Abstract

The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

DOI10.1039/c8cc04215b
URLView the original
Indexed BySCI ; IC ; CCR
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000440432600006
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYe, Min
Affiliation1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China
2.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
3.Peking Union Med Coll, Beijing 100050, Peoples R China
4.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
5.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
He, Junbin,Chen, Kuan,Hu, Zhi-min,et al. UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids[J]. CHEMICAL COMMUNICATIONS,2018,54(62):8594-8597.
APA He, Junbin.,Chen, Kuan.,Hu, Zhi-min.,Li, Kai.,Song, Wei.,...&Ye, Min.(2018).UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids.CHEMICAL COMMUNICATIONS,54(62),8594-8597.
MLA He, Junbin,et al."UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids".CHEMICAL COMMUNICATIONS 54.62(2018):8594-8597.
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