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Central role of autophagic UVRAG in melanogenesis and the suntan response
Yang, Yongfei; Jang, Gyu-beom; Yang, Xuanjun; Wang, Qiaoxiu; He, Shanshan; Li, Shun; Quach, Christine; Zhao, Shihui; Li, Fan; Yuan, Zengqiang; Lee, Hye-Ra; Zhong, Hanbing; Liang, Chengyu
2018-08-14
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume115Issue:33Pages:E7728-E7737
AbstractUV-induced cell pigmentation represents an important mechanism against skin cancers. Sun-exposed skin secretes alpha-MSH, which induces the lineage-specific transcriptional factor MITF and activates melanogenesis in melanocytes. Here, we show that the autophagic tumor suppressor UVRAG plays an integral role in melanogenesis by interaction with the biogenesis of lysosome-related organelles complex 1 (BLOC-1). This interaction is required for BLOC-1 stability and for BLOC-1-mediated cargo sorting and delivery to melanosomes. Absence of UVRAG dispersed BLOC-1 distribution and activity, resulting in impaired melanogenesis in vitro and defective melanocyte development in zebrafish in vivo. Furthermore, our results establish UVRAG as an important effector for melanocytes' response to alpha-MSH signaling as a direct target of MITF and reveal the molecular basis underlying the association between oncogenic BRAF and compromised UV protection in melanoma.
KeywordUVRAG MITF BLOC-1 melanosome BRAF
DOI10.1073/pnas.1803303115
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000441638200012
PublisherNATL ACAD SCIENCES
The Source to ArticleWOS
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Yang, Yongfei,Jang, Gyu-beom,Yang, Xuanjun,et al. Central role of autophagic UVRAG in melanogenesis and the suntan response[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018,115(33):E7728-E7737.
APA Yang, Yongfei.,Jang, Gyu-beom.,Yang, Xuanjun.,Wang, Qiaoxiu.,He, Shanshan.,...&Liang, Chengyu.(2018).Central role of autophagic UVRAG in melanogenesis and the suntan response.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(33),E7728-E7737.
MLA Yang, Yongfei,et al."Central role of autophagic UVRAG in melanogenesis and the suntan response".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115.33(2018):E7728-E7737.
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