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A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy
Xing, Lei1,2,3,4; Zhang, Jia-Liang1,5; Zhou, Tian-Jiao1; He, Yu-Jing1; Cui, Peng-Fei1; Gong, Jia-Hui1; Sun, Minjie1; Lu, Jin-Jian6; Huang, Zhangjian1,4; Jin, Liang1,7; Jiang, Hu-Lin1,2,3,4
2018-08-14
Source PublicationCHEMICAL COMMUNICATIONS
ISSN1359-7345
Volume54Issue:63Pages:8737-8740
Abstract

We report a novel and easy-to-fabricate polynuclear nanoparticle based on the collaborative re-assembly of nanoparticles as a robust chemogene co-delivery platform. Specifically, the polynuclear nanoparticle carrying DOX and siBcl-2 exerts remarkable co-delivery efficiency, increases tumour cell apoptosis and inhibits tumour cell proliferation in vitro and in vivo.

DOI10.1039/c8cc03720e
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000446058700015
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
Fulltext Access
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
2.Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, China
3.Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China
4.Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, China
5.Department of Pharmacy, Dong Fang Hospital (Fuzhou General Hospital), Medical College of Xiamen University, Xiamen University, Fouzhou 350025, China
6.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
7.School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
Recommended Citation
GB/T 7714
Xing, Lei,Zhang, Jia-Liang,Zhou, Tian-Jiao,et al. A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy[J]. CHEMICAL COMMUNICATIONS,2018,54(63):8737-8740.
APA Xing, Lei.,Zhang, Jia-Liang.,Zhou, Tian-Jiao.,He, Yu-Jing.,Cui, Peng-Fei.,...&Jiang, Hu-Lin.(2018).A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy.CHEMICAL COMMUNICATIONS,54(63),8737-8740.
MLA Xing, Lei,et al."A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy".CHEMICAL COMMUNICATIONS 54.63(2018):8737-8740.
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