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Activatable photoacoustic and fluorescent probe of nitric oxide for cellular and in vivo imaging
Wang, Shichao; Li, Zhi; Liu, Yubin; Feng, Gang; Zheng, Jun; Yuan, Zhen; Zhang, Xuanjun
2018-08-15
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
Volume267Pages:403-411
Abstract

This article describes an effective probe PS for the detection of nitric oxide (NO), which can be monitored by both fluorescence and photoacoustic signals. PS contains two diphenylamine groups as electron donors conjugated to both ends of the molecule and benzothiadiazolediamine as electron acceptor and act as reaction moiety as well. The electron-rich aromatic diamine can react with NO under the aerobic condition to form a five-member ring, resulting in the increase of electron withdrawing of the acceptor moiety thus increase intramolecular charge transfer (ICT) in the Donor-Acceptor-Donor (D-A-D) structure. Probe PS has a fast fluorescence on-off response and excellent selectivity for NO over various reactive oxygen/nitrogen species (ROS/RNS) and AA, MGO. PS can also work as an effective photoacoustic (PA) probe towards NO with the off-on photoacoustic signal response due to large absorption change between the probe PS (368 nm) and its NO reactant PS-NO (568 nm). Further, probe PS was successfully applied to the detection of endogenous NO in RAW264.7 cells by fluorescence imaging and lipopolysaccharide-induced inflammation mice model by PA imaging. (C) 2018 Elsevier B.V. All rights reserved.

KeywordPhotoacoustic Fluorescence Nitric Oxide Ict Sensing
DOI10.1016/j.snb.2018.04.052
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS IDWOS:000432775600048
PublisherELSEVIER SCIENCE SA
The Source to ArticleWOS
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationFaculty of Health Sciences, University of Macau, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Wang, Shichao,Li, Zhi,Liu, Yubin,et al. Activatable photoacoustic and fluorescent probe of nitric oxide for cellular and in vivo imaging[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,267:403-411.
APA Wang, Shichao.,Li, Zhi.,Liu, Yubin.,Feng, Gang.,Zheng, Jun.,...&Zhang, Xuanjun.(2018).Activatable photoacoustic and fluorescent probe of nitric oxide for cellular and in vivo imaging.SENSORS AND ACTUATORS B-CHEMICAL,267,403-411.
MLA Wang, Shichao,et al."Activatable photoacoustic and fluorescent probe of nitric oxide for cellular and in vivo imaging".SENSORS AND ACTUATORS B-CHEMICAL 267(2018):403-411.
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