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Iridium-based probe for luminescent nitric oxide monitoring in live cells
Wu, Chun1; Wu, Ke-Jia2; Kang, Tian-Shu2; Wang, Hui-Min David3; Leung, Chung-Hang2; Liu, Jin-Biao1,4; Ma, Dik-Lung1
2018-08-20
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume8
Abstract

Nitric oxide (NO) is an intra- and extracellular messenger with important functions during human physiology process. A long-lived luminescent iridium(III) complex probe 1 has been designed and synthesized for the monitoring of NO controllably released from sodium nitroprusside (SNP). Probe 1 displayed a 15-fold switch-on luminescence in the presence of SNP at 580 nm. The probe exhibited a linear response towards SNP between 5 to 25 mu M with detection limit at 0.18 mu M. Importantly, the luminescent switch-on detection of NO in HeLa cells was demonstrated. Overall, complex 1 has the potential to be applied for NO tracing in complicated cellular environment.

DOI10.1038/s41598-018-30991-9
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000442131600025
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
2.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
3.Natl Chung Hsing Univ, Grad Inst Biomed Engn, Taichung, Taiwan
4.Jiangxi Univ Sci & Technol, Sch Met & Chem Engn, Ganzhou, Peoples R China
Recommended Citation
GB/T 7714
Wu, Chun,Wu, Ke-Jia,Kang, Tian-Shu,et al. Iridium-based probe for luminescent nitric oxide monitoring in live cells[J]. SCIENTIFIC REPORTS,2018,8.
APA Wu, Chun.,Wu, Ke-Jia.,Kang, Tian-Shu.,Wang, Hui-Min David.,Leung, Chung-Hang.,...&Ma, Dik-Lung.(2018).Iridium-based probe for luminescent nitric oxide monitoring in live cells.SCIENTIFIC REPORTS,8.
MLA Wu, Chun,et al."Iridium-based probe for luminescent nitric oxide monitoring in live cells".SCIENTIFIC REPORTS 8(2018).
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