| Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging | |
| Couto，Tania Alexandra1,2; Xu，Shiyang1,2; Da Silva，Paulo Armada3; Wu，Chenggang1,4,5; Neergaard，Karl1; Wang，Meng Yun1,2; Zhang，Juan1,3; Xiang，Yutao1,3; Yuan，Zhen1,2 | |
| 2020 | |
| Source Publication | Neural Plasticity
 |
| ISSN | 2090-5904 |
| Volume | 2020 |
| Abstract | The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during figurative language comprehension. The method is aimed at mapping significant causal relationships across language brain networks, captured by functional near-infrared spectroscopy measurements (fNIRS): (i) definition of regions of interest (ROIs) based on significant channels extracted from spatial activation maps; (ii) inspection of significant causal relationships in temporal resolution, exploring the experimental task agreement; and (iii) early identification of stronger causal relationships that guide neuromodulation intervention, targeting impaired connectivity pathways. Our results propose top-down mechanisms responsible for perceptive-attention engagement in the left anterior frontal cortex and bottom-up mechanism in the right hemispheres during the semantic integration of figurative language. Moreover, the interhemispheric directional flow suggests a right hemisphere engagement in decoding unfamiliar literal sentences and fine-grained integration guided by the left hemisphere to reduce ambiguity in meaningless words. Finally, bottom-up mechanisms seem activated by logographic-semantic processing in literal meanings and memory storage centres in meaningless comprehension. To sum up, our main findings reveal that the Granger Prediction Estimation (GPE) integrated strategy proposes an effective link between assessment and intervention, capable of enhancing the efficiency of the treatment in language disorders and reducing the neuromodulation side effects. |
| DOI | 10.1155/2020/8882207 |
| URL | View the original |
| Language | 英语 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Corresponding Author | Yuan，Zhen |
| Affiliation | 1.Centre for Cognitive and Brain Sciences,University of Macau,Macau S.A.R.,Macao 2.Faculty of Health Sciences,University of Macau,Macau S.A.R.,Macao 3.Faculty of Human Kinetics,University of Lisbon,Lisbon,Portugal 4.Faculty of Education,University of Macau,Macau S.A.R.,Macao 5.School of Education,Shanghai International Studies University,Shanghai,China |
| First Author Affilication | University of Macau; Faculty of Health Sciences |
| Corresponding Author Affilication | University of Macau; Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | Couto，Tania Alexandra,Xu，Shiyang,Da Silva，Paulo Armada,et al. Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging[J]. Neural Plasticity,2020,2020. |
| APA | Couto，Tania Alexandra.,Xu，Shiyang.,Da Silva，Paulo Armada.,Wu，Chenggang.,Neergaard，Karl.,...&Yuan，Zhen.(2020).Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging.Neural Plasticity,2020. |
| MLA | Couto，Tania Alexandra,et al."Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging".Neural Plasticity 2020(2020). |
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