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Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children With Down's Syndrome: An fNIRS Study
Xu,Shi Yang1,2; Lu,Feng Mei1,3; Wang,Meng Yun1; Hu,Zhi Shan1; Zhang,Juan4; Chen,Zhi Yi5; Armada-da-Silva,Paulo A.S.6,7; Yuan,Zhen1,2
2020-02-14
Source PublicationFrontiers in Human Neuroscience
Volume14
AbstractChildren with Down's syndrome (DS) might exhibit disrupted brain functional connectivity in the motor and prefrontal cortex. To inspect the alterations in brain activation and functional connectivity for children with DS, the functional near-infrared spectroscopy (fNIRS) method was applied to examine the brain activation difference in the motor and prefrontal cortex between the DS and typically developing (TD) groups during a fine motor task. In addition, small-world analysis based on graph theory was also carried out to characterize the topological organization of functional brain networks. Interestingly, behavior data demonstrated that the DS group showed significantly long reaction time and low accuracy as compared to the TD group (p < 0.05). More importantly, significantly reduced brain activations in the frontopolar area, the pre-motor, and the supplementary motor cortex (p < 0.05) were identified in the DS group compared with the TD group. Meanwhile, significantly high global efficiency (E) and short average path length (L) were also detected for the DS group. This pilot study illustrated that the disrupted connectivity of frontopolar area, pre-motor, and supplementary motor cortex might be one of the core mechanisms associated with motor and cognitive impairments for children with DS. Therefore, the combination of the fNIRS technique with functional network analysis may pave a new avenue for improving our understanding of the neural mechanisms of DS.
Keywordbrain connectivity children cognition Down's syndrome fNIRS
DOI10.3389/fnhum.2020.00006
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorYuan,Zhen
Affiliation1.Faculty of Health Sciences,University of Macau,Macao
2.Centre for Cognitive and Brain Sciences,University of Macau,Macao
3.MOE Key Laboratory for Neuroinformation,The Clinical Hospital of Chengdu Brain Science Institute,University of Electronic Science and Technology of China,Chengdu,China
4.Faculty of Education,University of Macau,Macao
5.Department of Ultrasound Medicine,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,China
6.Faculty of Human Kinetics,University of Lisbon,Cruz Quebrada,Portugal
7.Neuromechanics of Human Movement,Faculty of Human Kinetics,CIPER,University of Lisbon,Lisbon,Portugal
First Author AffilicationFaculty of Health Sciences;  University of Macau
Corresponding Author AffilicationFaculty of Health Sciences;  University of Macau
Recommended Citation
GB/T 7714
Xu,Shi Yang,Lu,Feng Mei,Wang,Meng Yun,et al. Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children With Down's Syndrome: An fNIRS Study[J]. Frontiers in Human Neuroscience,2020,14.
APA Xu,Shi Yang.,Lu,Feng Mei.,Wang,Meng Yun.,Hu,Zhi Shan.,Zhang,Juan.,...&Yuan,Zhen.(2020).Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children With Down's Syndrome: An fNIRS Study.Frontiers in Human Neuroscience,14.
MLA Xu,Shi Yang,et al."Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children With Down's Syndrome: An fNIRS Study".Frontiers in Human Neuroscience 14(2020).
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