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Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network
Siyao Hu1; Huali Zuo2; Jin Qi1; Yuanjia Hu2; Boyang Yu1
2019-03-20
Source PublicationFRONTIERS IN PHARMACOLOGY
ISSN1663-9812
Volume10
Other Abstract

Schisandra chinensis is a commonly used traditional Chinese medicine, which has been widely used in the treatment of acute myocardial infarction in China. However, it has been difficult to systematically clarify the major pharmacological effect of Schisandra, due to its multi-component complex mechanism. In order to solve this problem, a comprehensive network analysis method was established based-on “component– gene ontology–effect” interactions. Through the network analysis, reduction of cardiac preload and myocardial contractility was shown to be the major effect of Schisandra components, which was further experimentally validated. In addition, the expression of NCOR2 and NFAT in myocyte were experimentally confirmed to be associated with Schisandra in the treatment of AMI, which may be responsible for the preservation effect of myocardial contractility. In conclusion, the three-mode gene ontology network can be an effective network analysis workflow to evaluate the pharmacological effects of a multi-drug complex system.

KeywordSchisandra Myocardial Infarction Effect Three-mode Network Gene Ontology
DOI10.3389/fphar.2019.00232
Indexed BySCIE
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000461811900001
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYuanjia Hu; Boyang Yu
Affiliation1.Jiangsu Key Laboratory of Traditional Medicine and Translational Research, China Pharmaceutical University, Nanjing, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Siyao Hu,Huali Zuo,Jin Qi,et al. Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network[J]. FRONTIERS IN PHARMACOLOGY,2019,10.
APA Siyao Hu,Huali Zuo,Jin Qi,Yuanjia Hu,&Boyang Yu.(2019).Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network.FRONTIERS IN PHARMACOLOGY,10.
MLA Siyao Hu,et al."Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network".FRONTIERS IN PHARMACOLOGY 10(2019).
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