UM
cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia
Wang, Haitao; Xu, Jiangping; Lazarovici, Philip; Quirion, Remi; Zheng, Wenhua
2018-08-30
Source PublicationFRONTIERS IN MOLECULAR NEUROSCIENCE
ISSN1662-5099
Volume11
AbstractDopamine is a brain neurotransmitter involved in the pathology of schizophrenia. The dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is hyperactive. The cAMP-response element binding protein (CREB) is an intracellular protein that regulates the expression of genes that are important in dopaminergic neurons. Dopamine affects the phosphorylation of CREB via G protein-coupled receptors. Neurotrophins, such as brain derived growth factor (BDNF), are critical regulators during neurodevelopment and synaptic plasticity. The CREB is one of the major regulators of neurotrophin responses since phosphorylated CREB binds to a specific sequence in the promoter of BDNF and regulates its transcription. Moreover, susceptibility genes associated with schizophrenia also target and stimulate the activity of CREB. Abnormalities of CREB expression is observed in the brain of individuals suffering from schizophrenia, and two variants (-933T to C and -413G to A) were found only in schizophrenic patients. The CREB was also involved in the therapy of animal models of schizophrenia. Collectively, these findings suggest a link between CREB and the pathophysiology of schizophrenia. This review provides an overview of CREB structure, expression, and biological functions in the brain and its interaction with dopamine signaling, neurotrophins, and susceptibility genes for schizophrenia. Animal models in which CREB function is modulated, by either overexpression of the protein or knocked down through gene deletion/mutation, implicating CREB in schizophrenia and antipsychotic drugs efficacy are also discussed. Targeting research and drug development on CREB could potentially accelerate the development of novel medications against schizophrenia.
KeywordCREB schizophrenia neurotransmitter neurodevelopment dopamine
DOI10.3389/fnmol.2018.00255
URLView the original
Indexed BySCI ; SSCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000443186500001
PublisherFRONTIERS MEDIA SA
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Wang, Haitao,Xu, Jiangping,Lazarovici, Philip,et al. cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2018,11.
APA Wang, Haitao,Xu, Jiangping,Lazarovici, Philip,Quirion, Remi,&Zheng, Wenhua.(2018).cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia.FRONTIERS IN MOLECULAR NEUROSCIENCE,11.
MLA Wang, Haitao,et al."cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia".FRONTIERS IN MOLECULAR NEUROSCIENCE 11(2018).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Haitao]'s Articles
[Xu, Jiangping]'s Articles
[Lazarovici, Philip]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Haitao]'s Articles
[Xu, Jiangping]'s Articles
[Lazarovici, Philip]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Haitao]'s Articles
[Xu, Jiangping]'s Articles
[Lazarovici, Philip]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.