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The effects of CACNA1C gene polymorphism on prefrontal cortex in both schizophrenia patients and healthy controls
Zhifang Zhang1; Yanyan Wang2; Qiumei Zhang1,3; Wan Zhao1; Xiongying Chen1; Jinguo Zhai3; Min Chen3; Boqi Du1; Xiaoxiang Deng1; Feng Ji3; Chuanyue Wang4; Yutao Xiang4,5; Dawei Li6; Hongjie Wu7; Qi Dong1; Chuansheng Chen8; Jun Li1
2019-02
Source PublicationSchizophrenia Research
ISSN0920-9964
Volume204Pages:193-200
Abstract

CACNA1Cgene polymorphism rs2007044 has been reported to be associated with schizophrenia, but its under-lying brain mechanism is not clear. First, we conducted an exploratory functional magnetic resonance imaging(fMRI) study using an N-BACK task and a Stroop task in 194 subjects (55 schizophrenia patients and 139 healthycontrols). Our whole brain analysis found that the risk allele was associated with reduced activation of the leftinferior frontal gyrus (IFG) during the Stroop task (cluster size = 390 voxels,Pb0.05 TFCE-FWE corrected;peak MNI coordinates: x =−57, y =−6, z = 30). We also conducted a functional near-infrared spectroscopy(fNIRS) study using the same Stroop task in an independent sample of 126 healthy controls to validate thefMRIfinding. Our repeated-measures ANCOVA on the six channels (20, 27, 33, 34, 40 and 46) within the leftIFG also found significant result. The polymorphism rs2007044 showed significant effect on the oxy-Hb data(F = 5.072,P= 0.026) and showed significant interaction effect with channels on the deoxy-Hb data (F =2.841,P= 0.015). Taken together, results of this study suggested that rs2007044 could affect the activation ofthe left IFG, which was a possible brain mechanism underlying the association betweenCACNA1Cgene polymor-phism and schizophrenia.

KeywordCacna1c Gene Cognitive Function Fmri Fnirs Inferior Frontal Gyrus
DOI10.1016/j.schres.2018.09.007
Indexed BySSCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000460113900029
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorJun Li
Affiliation1.State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China
2.Department of Psychiatry, HePing Hospital of Chang Zhou, Jiangsu 213003, China
3.School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining 272013, Shandong Province, PR China
4.Beijing Anding Hospital, Beijing 100088, PR China
5.Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau
6.Center for Cognitive Neuroscience, Duke University, Durham, NC, USA
7.Shengli Hospital of Shengli Petroleum Administration Bureau, Dongying 257022, Shandong Province, PR China
8.Department of Psychology and Social Behavior, University of California, Irvine, CA 92697, United States
Recommended Citation
GB/T 7714
Zhifang Zhang,Yanyan Wang,Qiumei Zhang,et al. The effects of CACNA1C gene polymorphism on prefrontal cortex in both schizophrenia patients and healthy controls[J]. Schizophrenia Research,2019,204:193-200.
APA Zhifang Zhang.,Yanyan Wang.,Qiumei Zhang.,Wan Zhao.,Xiongying Chen.,...&Jun Li.(2019).The effects of CACNA1C gene polymorphism on prefrontal cortex in both schizophrenia patients and healthy controls.Schizophrenia Research,204,193-200.
MLA Zhifang Zhang,et al."The effects of CACNA1C gene polymorphism on prefrontal cortex in both schizophrenia patients and healthy controls".Schizophrenia Research 204(2019):193-200.
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