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Rates and predictors of one-year antipsychotic treatment discontinuation in first-episode schizophrenia: Results from an open-label, randomized, "real world" clinical trial
Cheng Zhang1; Yuan Yanbo1; Han Xue1; Yang Lei1; Zeng Xin2; Yang Fude3; Lu Zheng4; Wang Chuanyue5; Deng Hong6; Zhao Jingping7; Xiang Yu-Tao8; Christoph U. Correll9,10,11; Yu Xin1
2019-03
Source PublicationPsychiatry Research
ISSN0165-1781
Volume273Pages:631-640
Abstract

Antipsychotic treatment discontinuation is a major challenge in the treatment of first-episode schizophrenia (FES) patients. However, the rate and predictors remain unclear. Five hundred and sixty-nine FES patients were randomized to risperidone (n = 190), olanzapine (n = 185) or aripiprazole (n = 194) in a six-site study in China with 1-year follow-up. Patients failing the initially assigned antipsychotic were switched to one of the other 2 antipsychotics. By 52 weeks, 47.1% of FES patients discontinued all antipsychotics. In the 8-week acute phase, an antipsychotic switch was protective against antipsychotic discontinuation, whereas higher positive symptoms at the endpoint predicted discontinuation. In the maintenance phase, discontinuation was predicted by male gender and higher CGI-S score at the endpoint. The findings indicate that in China nearly half of patients with FES discontinued antipsychotic treatment during one year treatment. Clinicians should employ strategies other than medication choice to keep them from discontinuing.

KeywordFirst-episode Antipsychotic Discontinuation Predictors Schizophrenia
DOI10.1016/j.psychres.2019.01.068
Indexed BySSCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000465059400089
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorCheng Zhang; Yuan Yanbo; Han Xue; Yang Lei; Zeng Xin; Yang Fude; Lu Zheng; Wang Chuanyue; Deng Hong; Zhao Jingping; Xiang Yu-Tao; Christoph U. Correll; Yu Xin
Affiliation1.Institute of Mental Health, Peking University, Huayuanbei 51, Haidian District, Beijing, 100191, China
2.Peking University Clinical Research Institute, Beijing, China
3.Beijing Hui-Long-Guan Hospital, Beijing, China
4.Tongji Hospital of Tongji University, Shanghai, China
5.Beijing Anding Hospital, Capital Medical University, Beijing, China
6.West China Hospital, Sichuan University, Chengdu, China
7.Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China
8.Unit of Psychiatry, Faculty of Health Science, University of Macau, Macao SAR, China
9.The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA
10.Hofstra Northwell School of Medicine, Hempstead, NY, USA
11.The Feinstein Institute for Medical Research, Manhasset, NY, USA
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Cheng Zhang,Yuan Yanbo,Han Xue,et al. Rates and predictors of one-year antipsychotic treatment discontinuation in first-episode schizophrenia: Results from an open-label, randomized, "real world" clinical trial[J]. Psychiatry Research,2019,273:631-640.
APA Cheng Zhang.,Yuan Yanbo.,Han Xue.,Yang Lei.,Zeng Xin.,...&Yu Xin.(2019).Rates and predictors of one-year antipsychotic treatment discontinuation in first-episode schizophrenia: Results from an open-label, randomized, "real world" clinical trial.Psychiatry Research,273,631-640.
MLA Cheng Zhang,et al."Rates and predictors of one-year antipsychotic treatment discontinuation in first-episode schizophrenia: Results from an open-label, randomized, "real world" clinical trial".Psychiatry Research 273(2019):631-640.
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