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Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging
Liu,Yubin1; Wu,Pei Chun1; Guo,Sen1; Chou,Pi Tai3; Deng,Chuxia1,2; Chou,Shang Wei3; Yuan,Zhen1,2; Liu,Tzu Ming1,2
2020-09-01
Source PublicationPhotoacoustics
ISSN2213-5979
Volume19
AbstractA considerable amount of early breast tumors grown at a depth over 2 cm in breast tissues. With high near-infrared absorption of iron-platinum (FePt) nanoparticles, we achieved few centimeters deep photoacoustic (PA) imaging for the diagnosis of breast tumors. The imaging depth can extend over 5 cm in chicken breast tissues at the low laser energy density of 20 mJ/cm (≤ ANSI safety limit). After anti-VEGFR conjugation and the tail-vein injection, we validated their targeting on tumor sites by the confocal microscopy and PA imaging. Using a home-made whole-body in vivo PA imaging, we found that the nanoparticles were rapidly cleared away from the site of the tumor and majorly metabolized through the liver. These results validated the clinical potential of the FePt nanoparticles in the low-toxicity PA theragnosis of early breast cancer and showed the capacity of our whole-body PA imaging technique on monitoring the dynamic biodistribution of nanoparticles in the living body.
KeywordBreast cancer FePt nanoparticles Imaging depth Whole-body photoacoustic imaging
DOI10.1016/j.pacs.2020.100179
URLView the original
Language英语
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYuan,Zhen
Affiliation1.Cancer Center,Faculty of Health Sciences,University of Macau,Macau SAR,China
2.Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macau SAR,China
3.Department of Chemistry,National Taiwan University,Taipei,10617,Taiwan
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Liu,Yubin,Wu,Pei Chun,Guo,Sen,et al. Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging[J]. Photoacoustics,2020,19.
APA Liu,Yubin.,Wu,Pei Chun.,Guo,Sen.,Chou,Pi Tai.,Deng,Chuxia.,...&Liu,Tzu Ming.(2020).Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging.Photoacoustics,19.
MLA Liu,Yubin,et al."Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging".Photoacoustics 19(2020).
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