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Supramolecular formulation of nitidine chloride can alleviate its hepatotoxicity and improve its anticancer activity
Li, Wanying1; Yin, Hang1; Bardelang, David2; Xiao, Jianbo1; Zheng, Ying1; Wang, Ruibing1
2017-11
Conference Name9th International Symposium on Natural Products Chemistry and Applications
Source PublicationFOOD AND CHEMICAL TOXICOLOGY
Volume109
Pages923-929
Conference DateNOV 22-25, 2016
Conference PlaceChillan, CHILE
Publication PlaceTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Abstract

Nitidine chloride (NC) has demonstrated promising anticancer activity. However, NC has also shown nonspecific toxicity in various healthy organs such as the liver. In this study, we aimed to develop a supramolecular formulation of NC and investigate the associated benefits of such a supramolecular formulation on modulating its inherent hepatotoxicity and anticancer activity. The formation of NC-cucurbit[7]uil (NC@CB[7]) complexes was characterized by H-1 nuclear magnetic resonance and Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffraction analysis. As a consequence of the supramolecular complexation, NC@CB[7] showed significantly lower toxicity (IC50: 6.87 +/- 0.80 mu M) on a liver cell line (LO2), and higher cytotoxicity (IC50: 2.94 +/- 0.15 mu M) on a breast cancer cell line (MCF-7), when compared with the free drug (IC50 of 3.48 +/- 0.49 mu M and 7.28 +/- 0.36 mu M, on these two cell lines, respectively). Investigation of cellular uptakes revealed that CB[7]'s capability in modulating the toxicity/activity of NC was mainly attributed to the drug's different cellular uptake behaviors that were influenced by CB[7]'s complexation. Taken together, we have demonstrated that supramolecular formulation of NC by CB(7] significantly alleviated its hepatotoxicity and improved its anticancer activity in vitro. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordNitidine Chloride Cucurbit[7] Uril Supramolecular Formulation Hepatotoxicity Anticancer Activity
DOIhttp://doi.org/10.1016/j.fct.2017.02.022
URLView the original
Indexed BySCI ; CPCI
Language英语
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000415911500012
The Source to ArticleWOS
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
2.Aix Marseille Univ, CNRS, ICR, Marseille, France
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Wanying,Yin, Hang,Bardelang, David,et al. Supramolecular formulation of nitidine chloride can alleviate its hepatotoxicity and improve its anticancer activity[C]. THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND:PERGAMON-ELSEVIER SCIENCE LTD,2017:923-929.
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