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Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes
Zhu-Jun Fang1; Sheng-Nan Shen2; Jia-Min Wang1; Yong-Jiang Wu1; Chang-Xin Zhou1; Jian-Xia Mo1; Li-Gen Lin2; Li-She Gan1,3
Source PublicationMOLECULES

Four previously undescribed compounds, including three rarely occurring seco-dammarane triterpenoid glycosides and a pentacyclic triterpenic acid, were isolated from a 70% ethanol extract of the leaves of Cyclocarya paliurus (Juglandaceae), along with eleven known triterpenoids. Their structures were determined by spectroscopic techniques, including 2D NMR and HRESIMS, as well as chemical methods. Among them, several triterpenoids enhanced insulin stimulated glucose uptake in both 3T3-L1 adipocytes and C2C12 myotubes. Furthermore, compound 1 dose-dependently increased glucose uptake through activating AMP-activated protein kinase (AMPK)-p38 pathway. Collectively, triterpenoids from C. paliurus could be developed as insulin sensitizers, which might have therapeutic potential for insulin resistance and hyperglycemia.

KeywordCyclocarya Paliurus (Juglandaceae) Seco-dammarane Triterpenoids Glucose Uptake Adipocytes
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000457150200187
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
Institute of Chinese Medical Sciences
Corresponding AuthorLi-Gen Lin; Li-She Gan
Affiliation1.College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
3.Hangzhou Institute of Innovative Medicine, Zhejiang University, 291 Fucheng Road, Hangzhou 310018, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhu-Jun Fang,Sheng-Nan Shen,Jia-Min Wang,et al. Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes[J]. MOLECULES,2019,24(1).
APA Zhu-Jun Fang.,Sheng-Nan Shen.,Jia-Min Wang.,Yong-Jiang Wu.,Chang-Xin Zhou.,...&Li-She Gan.(2019).Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes.MOLECULES,24(1).
MLA Zhu-Jun Fang,et al."Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes".MOLECULES 24.1(2019).
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