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Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging
Yip, Bill W. P.1; Mok, Helen O. L.1; Peterson, Drew R.1; Wan, Miles T.1; Taniguchi, Y.2; Ge, Wei3; Au, Doris W. T.1
2017-11-30
Source PublicationMARINE POLLUTION BULLETIN
ISSN0025-326X
Volume124Issue:2Pages:701-709
Abstract

Marine medaka Otyzias melastigma at 4 months (young), 8 months (middle-aged) and 12 months old (senior) were employed to determine age-associated change of sex ratios, sex hormones, telomere length (TL), telomerase activity (TA), telomerase transcription (omTERT) and oxidative damage in the liver. Overall, O. melastigma exhibited gradual senescence, sex differences in longevity (F> M), TL (F> M) and oxidative damage (F < M) during aging. In females, the plasma E2 level was positively correlated with TL (TRF> 5 kb), TA and omTERT expression (p <= 5.0.01), and negatively correlated with liver DNA oxidation (p <= 0.05).The results suggest high levels of E2 in female O. melastigma may retard TL shortening by enhancing TA via TERT transcription and/or reducing oxidative DNA damage. The findings support TL shortening as a biomarker of aging and further development of accelerated TL shortening, abnormal suppression of TA and excessive oxidative DNA damage as early molecular endpoints, indicative of advanced/premature aging in marine medaka/fish. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordSex Hormones Telomerase And Telomere Tert 8-ohdg Protein Carbonyl Biomarker Of Aging Longevity Gender Gap Post-menopausal Decline Of E2
DOI10.1016/j.marpolbul.2017.01.021
URLView the original
Indexed BySCI ; CPCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Marine & Freshwater Biology
WOS SubjectEnvironmental Sciences ; Marine & Freshwater Biology
WOS IDWOS:000417964500017
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.State Key Laboratory in Marine Pollution, Department of Biology and Chemistry, City University of Hong Kong, Hong Kong
2.Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University, Tokyo, 181-8611, Japan
3.Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China
Recommended Citation
GB/T 7714
Yip, Bill W. P.,Mok, Helen O. L.,Peterson, Drew R.,et al. Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging[J]. MARINE POLLUTION BULLETIN,2017,124(2):701-709.
APA Yip, Bill W. P..,Mok, Helen O. L..,Peterson, Drew R..,Wan, Miles T..,Taniguchi, Y..,...&Au, Doris W. T..(2017).Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging.MARINE POLLUTION BULLETIN,124(2),701-709.
MLA Yip, Bill W. P.,et al."Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging".MARINE POLLUTION BULLETIN 124.2(2017):701-709.
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