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Multispectral photoacoustic imaging of cancer with broadband CuS nanoparticles covering both near-infrared I and II biological windows
Yubin Liu; Duyang Gao; Mengze Xu; Zhen Yuan
2019-03
Source PublicationJOURNAL OF BIOPHOTONICS
ISSN1864-063X
Volume12Issue:3
Abstract

In this study, CuS nanoparticles with optical absorption covering both nearinfrared I (NIR-I) and NIR-II biological windows were prepared and served as the contrast agents for multispectral photoacoustic imaging. The physiological parameters including concentrations of deoxyhemoglobin and oxyhemoglobin as well as the water content in the tumor location were quantified based on the multispectral photoacoustic reconstruction method. More importantly, the concentration of CuS nanoparticles/drugs accumulated in the tumor was also recovered after intravenously injection, which are essential for image-guided cancer theranostics. In addition, phantom and in vivo experimental tests were performed to inspect and compare the imaging depth and signal-to-noise ratio (SNR) between the two NIR biological windows. Interestingly, we discovered that a higher SNR was obtained in the NIR-II window than that in the NIR-I window. Meanwhile, the multispectral imaging results also demonstrated that the imaging contrast and penetration depth in the NIR-II window were also significantly improved as compared to those from the NIR-I window.

KeywordCus Nanoparticles Nir-ii Biological Windows Photoacoustic Imaging Quantitative Imaging Multispectral
DOI10.1002/jbio.201800237
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Optics
WOS SubjectBiochemical Research Methods ; Biophysics ; Optics
WOS IDWOS:000462683300007
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorZhen Yuan
AffiliationBioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yubin Liu,Duyang Gao,Mengze Xu,et al. Multispectral photoacoustic imaging of cancer with broadband CuS nanoparticles covering both near-infrared I and II biological windows[J]. JOURNAL OF BIOPHOTONICS,2019,12(3).
APA Yubin Liu,Duyang Gao,Mengze Xu,&Zhen Yuan.(2019).Multispectral photoacoustic imaging of cancer with broadband CuS nanoparticles covering both near-infrared I and II biological windows.JOURNAL OF BIOPHOTONICS,12(3).
MLA Yubin Liu,et al."Multispectral photoacoustic imaging of cancer with broadband CuS nanoparticles covering both near-infrared I and II biological windows".JOURNAL OF BIOPHOTONICS 12.3(2019).
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