UM  > 健康科學學院
Abnormal dynamic functional connectivity and brain states in Alzheimer's diseases: functional near-infrared spectroscopy study
Haijing Niu1; Zhaojun Zhu1; Mengjing Wang1; Xuanyu Li2; Zhen Yuan3; Yu Sun2; Ying Han2,4,5,6
2019-04
Source PublicationNEUROPHOTONICS
ISSN2329-423X
Volume6Issue:2
Abstract

Communication within the brain is highly dynamic. Alzheimer's disease (AD) exhibits dynamic progression corresponding to a decline in memory and cognition. However, little is known of whether brain dynamics are disrupted in AD and its prodromal stage, mild cognitive impairment (MCI). For our study, we acquired high sampling rate functional near-infrared spectroscopy imaging data at rest from the entire cortex of 23 patients with AD dementia, 25 patients with amnestic mild cognitive impairment (aMCI), and 30 age-matched healthy controls (HCs). Sliding-window correlation and k-means clustering analyses were used to construct dynamic functional connectivity (FC) maps for each participant. We discovered that the brain's dynamic FC variability strength (Q) significantly increased in both aMCI and AD group as compared to HCs. Using the Q value as a measurement, the classification performance exhibited a good power in differentiating aMCI [area under the curve (AUC = 82.5%)] or AD (AUC = 86.4%) from HCs. Furthermore, we identified two abnormal brain FC states in the AD group, of which the occurrence frequency (F) exhibited a significant decrease for the first-level FC state (state 1) and a significant increase for the second-level FC state (state 2). We also found that the abnormal F in these two states significantly correlated with the cognitive impairment in patients. These findings provide the first evidence to demonstrate the disruptions of dynamic brain connectivity in aMCI and AD and extend the traditional static (i.e., time-averaged) FC findings in the disease (i.e., disconnection syndrome) and thus provide insights into understanding the pathophysiological mechanisms occurring in aMCI and AD.

KeywordResting State Functional Connectivity Sliding-window K-means Clustering Brain Network Alzheimer's Disease
DOI10.1117/1.NPh.6.2.025010
Indexed BySCIE ; SSCI ; SSCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Optics
WOS SubjectNeurosciences ; Optics
WOS IDWOS:000481888400011
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorYu Sun; Ying Han
Affiliation1.Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing, China
2.Xuan Wu Hospital of Capital Medical University, Department of Neurology, Beijing, China
3.University of Macau, Faculty of Health Sciences, Macao, China
4.Beijing Institute for Brain Disorders, Center of Alzheimer’s Disease, Beijing, China
5.Beijing Institute of Geriatrics, Beijing, China
6.National Clinical Research Center for Geriatric Disorders, Beijing, China
Recommended Citation
GB/T 7714
Haijing Niu,Zhaojun Zhu,Mengjing Wang,et al. Abnormal dynamic functional connectivity and brain states in Alzheimer's diseases: functional near-infrared spectroscopy study[J]. NEUROPHOTONICS,2019,6(2).
APA Haijing Niu.,Zhaojun Zhu.,Mengjing Wang.,Xuanyu Li.,Zhen Yuan.,...&Ying Han.(2019).Abnormal dynamic functional connectivity and brain states in Alzheimer's diseases: functional near-infrared spectroscopy study.NEUROPHOTONICS,6(2).
MLA Haijing Niu,et al."Abnormal dynamic functional connectivity and brain states in Alzheimer's diseases: functional near-infrared spectroscopy study".NEUROPHOTONICS 6.2(2019).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Haijing Niu]'s Articles
[Zhaojun Zhu]'s Articles
[Mengjing Wang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Haijing Niu]'s Articles
[Zhaojun Zhu]'s Articles
[Mengjing Wang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Haijing Niu]'s Articles
[Zhaojun Zhu]'s Articles
[Mengjing Wang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.