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PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy
Hao Xu1,2; Yubin Liu2; Junle Qu1; Zhen Yuan2
2019-05
Source PublicationJOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
ISSN1793-5458
Volume12Issue:3
Abstract

The photosensitizer (PS) as photodynamic therapy (PDT) agent, can also serve as the contrast agent for dual-modal fluorescence imaging (FLI) and photoacoustic imaging (PAI) for precise cancer theranostics. In this study, the PAI capability of commercial PS, benzoporphyrin derivative monoacid ring-A (BPD) were examined and compared with that from the other PSs and dyes such as TPPS4, Cy5 dye and ICG. We discovered that BPD exhibited its advantage as contrast agent for PAI. Meanwhile, BPD can also serve as the contrast agent for enhanced FLI. In particular, the PEGylated nanoliposome (PNL) encapsulated BPD (LBPD) was produced for contrast enhanced dual-modal FLI and PAI and imaging-guided high-efficiency PDT. Enhanced FLI and PAI results demonstrated the significant accumulation of LBPD both within and among individual tumor during 24 h monitoring for in vivo experiment tests. In-vitro and in-vivo PDT tests were also performed, which showed that LBPD have higher PDT efficiency and can easily break the blood vessel of tumor tissues as compared to that from BPD. It was discovered that LBPD has great potentials as a diagnosis and treatment agent for dual-modal FLI and PAI-guided PDT of cancer.

KeywordLiposome Photosensitizer Photodynamic Therapy Photoacoustic Imaging Fluorescence Imaging
DOI10.1142/S1793545819410037
Indexed BySCIE
Language英语
WOS Research AreaOptics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectOptics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000470900500005
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorJunle Qu; Zhen Yuan
Affiliation1.College of Optoelectronic Engineering, Shenzhen University, Key Laboratory of Optoelectronic, Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen, Guangdong, P. R. China
2.Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, P. R. China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Hao Xu,Yubin Liu,Junle Qu,et al. PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy[J]. JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,2019,12(3).
APA Hao Xu,Yubin Liu,Junle Qu,&Zhen Yuan.(2019).PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy.JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,12(3).
MLA Hao Xu,et al."PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy".JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES 12.3(2019).
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