UM  > 健康科學學院
CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer
Houliang Deng1; Xiaowen Guan1; Longcai Gong1; Jianming Zeng1; Hongjie Zhang1; Mike Y. Chen2; Gang Li1
2019-01-17
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume9
Abstract

Chromobox 6 (CBX6) is a subunit of Polycomb Repressive Complex 1 (PRC1) that mediates epigenetic gene repression and acts as an oncogene or tumor suppressor in a cancer type-dependent manner. The specific function of CBX6 in breast cancer is currently undefined. In this study, a comprehensive analysis of The Cancer Genome Atlas (TCGA) dataset led to the identification of CBX6 as a consistently downregulated gene in breast cancer. We provided evidence showing enhancer of zeste homolog 2 (EZH2) negatively regulated CBX6 expression in a Polycomb Repressive Complex 2 (PRC2)-dependent manner. Exogenous overexpression of CBX6 inhibited cell proliferation and colony formation, and induced cell cycle arrest along with suppression of migration and invasion of breast cancer cells in vitro. Microarray analyses revealed that CBX6 governs a complex gene expression program. Moreover, CBX6 induced significant downregulation of bone marrow stromal cell antigen-2 (BST2), a potential therapeutic target, via interactions with its promoter region. Our collective findings support a tumor suppressor role of CBX6 in breast cancer.

DOI10.1038/s41598-018-36560-4
Indexed BySCIE
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000455951300045
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorGang Li
Affiliation1.Faculty of Health Sciences, University of Macau, Macau, China
2.Division of Neurosurgery, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Houliang Deng,Xiaowen Guan,Longcai Gong,et al. CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer[J]. SCIENTIFIC REPORTS,2019,9.
APA Houliang Deng.,Xiaowen Guan.,Longcai Gong.,Jianming Zeng.,Hongjie Zhang.,...&Gang Li.(2019).CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer.SCIENTIFIC REPORTS,9.
MLA Houliang Deng,et al."CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer".SCIENTIFIC REPORTS 9(2019).
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