UM  > 健康科學學院
Effects of Intranasal Cellulose Powder on Asthma Control in Children With Mild-to-Moderate Perennial Allergic Rhinitis: A Randomized, Placebo-Controlled Trial
Xi Chen1,2; Wei-jie Guan1; Shi-xue Sun3; Pei-yan Zheng1; Li-hong Sun1; De-hui Chen1; Dan-dan Wang3; Chang Chen3; Bao-qing Sun1; Xiao-hua Douglas Zhang3
2019-03
Source PublicationAMERICAN JOURNAL OF RHINOLOGY & ALLERGY
ISSN1945-8924
Volume33Issue:2Pages:184-193
Abstract

Background
Perennial allergic rhinitis (PAR) often coexists in asthmatic patients. Intranasal cellulose powder (ICP) was reportedly effective in ameliorating PAR.


Objective
We investigated whether ICP is equally effective compared with intranasal corticosteroids in improving asthma control as well as nasal symptoms among children with PAR and allergic asthma (AA).


Methods
Between July 2015 and September 2016, we did a single-center, randomized, placebo-controlled trial. Asthmatic children aged 6 to 11 years with mild-to-moderate PAR were randomly assigned to formoterol/budesonide inhalation (4·5 µg/80 µg, twice daily) plus intranasal budesonide 64 µg twice daily (group A), ICP 250 µg thrice daily (group B), or intranasal placebo 250 µg thrice daily (group C) for 8 weeks. The primary outcome was change in asthma control test for children (C-ACT) score from baseline to week 8 posttreatment. Changes in spirometry, peak expiratory flow (PEF), fractional exhaled nitric oxide (FeNO), and visual analog scale (VAS) for nasal and ocular symptoms were detected as secondary outcomes.


Results
We included 121 patients (38 in group A, 41 in group B, and 42 in group C) in full-analysis set. C-ACT score was markedly higher at week 8 compared with baseline (mean difference: 5.11, 6.05, and 4.85 points in groups A, B, and C, respectively; P < .05). There were interactions between baseline and treatment in C-ACT scores (P < .05). Group B demonstrated greater improvement in C-ACT score than group C among children with baseline C-ACT score of 6 to 18. 95% confidence intervals of group A at baseline overlapped with those of groups B and C. The treatment achieved reduced VAS symptoms in groups A and B but not in group C. Incidence of adverse events was comparable. No serious adverse event was reported.


Conclusions
ICP could be recommended for children with PAR and AA who have poorer asthma control.

KeywordIntranasal Cellulose Powder Intranasal Corticosteroids Asthma Perennial Allergic Rhinitis Asthma Control
DOI10.1177/1945892419826509
Indexed BySCIE
Language英语
WOS Research AreaOtorhinolaryngology
WOS SubjectOtorhinolaryngology
WOS IDWOS:000461441400012
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorBao-qing Sun; Xiao-hua Douglas Zhang
Affiliation1.Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
2.Department of Clinical Laboratory, Guangzhou Panyu Central Hospital, Guangzhou, China
3.Faculty of Health Sciences, University of Macau, Taipa, Macau
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Xi Chen,Wei-jie Guan,Shi-xue Sun,et al. Effects of Intranasal Cellulose Powder on Asthma Control in Children With Mild-to-Moderate Perennial Allergic Rhinitis: A Randomized, Placebo-Controlled Trial[J]. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY,2019,33(2):184-193.
APA Xi Chen.,Wei-jie Guan.,Shi-xue Sun.,Pei-yan Zheng.,Li-hong Sun.,...&Xiao-hua Douglas Zhang.(2019).Effects of Intranasal Cellulose Powder on Asthma Control in Children With Mild-to-Moderate Perennial Allergic Rhinitis: A Randomized, Placebo-Controlled Trial.AMERICAN JOURNAL OF RHINOLOGY & ALLERGY,33(2),184-193.
MLA Xi Chen,et al."Effects of Intranasal Cellulose Powder on Asthma Control in Children With Mild-to-Moderate Perennial Allergic Rhinitis: A Randomized, Placebo-Controlled Trial".AMERICAN JOURNAL OF RHINOLOGY & ALLERGY 33.2(2019):184-193.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xi Chen]'s Articles
[Wei-jie Guan]'s Articles
[Shi-xue Sun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xi Chen]'s Articles
[Wei-jie Guan]'s Articles
[Shi-xue Sun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xi Chen]'s Articles
[Wei-jie Guan]'s Articles
[Shi-xue Sun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.