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CELL MICROINJECTION SYSTEM WITH FORCE FEEDBACK
Qingsong XU
Rights HolderUniversity of Macau
Date Available2019-09-26
CountryUnited States
Subtype发明专利
Contribution Rank1
Abstract

A novel piezo-driven cell injection system with force feedback overcomes the unsatisfied force interaction between the pipette needle and embryos in conventional position control. By integrating semiconductor strain-gage sensors for detecting the cell penetration force and the micropipette relative position in real time, the developed cell microinjection system features high operation speed, confident success rate, and high survival rate. The effectiveness of the developed cell injection system is experimentally verified by penetrating zebrafish embryos. The injection of 100 embryos are conducted with separate position control and force control. Results indicate that the force control enables a survival rate of 86%, which is higher than the survival rate of 82% produced by the position control in the same control environment. The experimental results quantitatively demonstrate the superiority of force control over conventional position control for the first time.

Application Date2019-03-26
Patent NumberUS20190292567A1
Language英语
Application NumberUS16364458
Open (Notice) NumberUS20190292567A1
Fulltext Access
Document TypePatent
CollectionDEPARTMENT OF ELECTROMECHANICAL ENGINEERING
AffiliationUniversity of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Qingsong XU. CELL MICROINJECTION SYSTEM WITH FORCE FEEDBACK. US20190292567A1.
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