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Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern
Min Dong1; Liang-Nan Zeng1,2; Qinge Zhang3; Shu-Yu Yang4; Lian-Yu Chen5; Kang Sim6; Yan-Ling He7; Helen Fung-Kum Chiu8; Norman Sartorius9; Chay-Hoon Tan10; Mian-Yoon Chong11; Naotaka Shinfuku12; Shih-Ku Lin13; Chee H. Ng14; Gabor S. Ungvari15,16; Yu-Tao Xiang1
2019-11
Source PublicationJOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
ISSN0891-9887
Volume32Issue:6Pages:304-311
AbstractBackground and Objective: Antipsychotic polypharmacy (APP) is a controversial topic in the treatment of older adults with schizophrenia. The objective of this study was to examine the use of APP in older adult Asian patients with schizophrenia and its associated demographic and clinical factors. Methods: This study was based on the fourth survey of the consortium known as the Research on Asian Psychotropic Prescription Pattern for Antipsychotics. Fifteen Asian countries/territories participated in this survey, including Bangladesh, Mainland China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Myanmar, Pakistan, Singapore, Sri Lanka, Taiwan, Thailand, and Vietnam. Basic demographic and clinical characteristics were collected using a standardized data collection form. Results: Among the 879 older adults with schizophrenia included in the survey, the rate of APP was 40.5%. Multiple logistic regression analysis revealed that higher antipsychotic doses (P < .001, odds ratio [OR] = 1.003, 95% confidence interval [CI]: 1.002-1.003), longer duration of illness (P = .02, OR = 1.845, 95% CI: 1.087-3.132), and the prescription of anticholinergics (P < .001, OR = 1.871, 95% CI: 1.329-2.635), second-generation antipsychotics (P = .001, OR = 2.264, 95% CI: 1.453-3.529), and first-generation antipsychotics (P < .001, OR = 3.344, 95% CI: 2.307-4.847) were significantly associated with APP. Conclusion: Antipsychotic polypharmacy was common in older adult Asian patients with schizophrenia. Compared to the results of previous surveys, the use of APP showed a declining trend over time. Considering the general poor health status of older patients with schizophrenia and their increased risk of drug-induced adverse events, the use of APP in this population needs careful consideration.
KeywordSchizophrenia Older Adult Patients Antipsychotic Polypharmacy Asian
DOI10.1177/089198871986263
Indexed BySCI
Language英语
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology ; Psychiatry
WOS SubjectGeriatrics & Gerontology ; Clinical Neurology ; Psychiatry
WOS IDWOS:000484525300004
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, & Center for Cognition and Brain Sciences, University of Macau, Macao SAR, China
2.Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Sichuan Sheng, China
3.School of Mental Health, The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
4.Department of Pharmacy, Taipei City Hospital, Taipei, Taiwan
5.Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan
6.Institute of Mental Health, Buangkok Green Medical Park, Singapore
7.Department of Psychiatric Epidemiology, Shanghai Mental Health Center, Shanghai, China
8.Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
9.Association for the Improvement of Mental Health Programmes, Geneva, Switzerland
10.Department of Pharmacology, National University of Singapore, Singapore
11.Chiayi Chang Gung Memorial Hospital and School of Medicine, Chang Gung University, Chiayi, Taiwan
12.International Center for Medical Research, Kobe University School of Medicine, Kobe, Japan
13.Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan
14.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
15.University of Notre Dame Australia, Fremantle, Australia
16.Division of Psychiatry, School of Medicine, University of Western Australia, Perth, Australia
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Min Dong,Liang-Nan Zeng,Qinge Zhang,et al. Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern[J]. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,2019,32(6):304-311.
APA Min Dong.,Liang-Nan Zeng.,Qinge Zhang.,Shu-Yu Yang.,Lian-Yu Chen.,...&Yu-Tao Xiang.(2019).Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,32(6),304-311.
MLA Min Dong,et al."Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern".JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY 32.6(2019):304-311.
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