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Serum 25-Hydroxyvitamin D Levels and Depression in Older Adults: A Dose–Response Meta-Analysis of Prospective Cohort Studies
Haibin Li Ph.D.1,2; Dianqin Sun B.S.1; Anxin Wang Ph.D.1,2; Huiying Pan B.S.1; Wei Feng M.S.1,2; Chee H.NgM.B.B.S., M.D.3; Gabor S.UngvariM.D., Ph.D.4,5; Lixin Tao Ph.D.1,2; Xia Li Ph.D.6; Wei Wang M.D., Ph.D.7; Yu-Tao Xiang Ph.D.8; Xiuhua Guo Ph.D.1,2
2019-11
Source PublicationAMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
ISSN1064-7481
Volume27Issue:11Pages:1192-1202
AbstractObjective The association between serum vitamin D and risk of depression in older adults is controversial. We performed a dose–response meta-analysis of prospective cohort studies to examine the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and the risk of depression in older population. Methods Studies published before February 2018 in the PubMed, Cochrane Library, Web of Science, PsycINFO, and EMBASE databases were systematically searched. Prospective cohort studies that examined the association between serum 25(OH)D levels and the risk of depression in older adults were included. A random-effects model was used to calculate the pooled hazard ratio and the corresponding 95% confidence intervals. A nonlinear dose–response association was examined using restricted cubic spline functions. Results Six prospective studies covering 16,287 older adults with 1,157 cases of depression were included and analyzed. The pooled hazard ratio of depression for per 10-ng/mL increment in serum 25(OH)D was 0.88 (95% confidence intervals: 0.78–0.99, I2 = 79.0%, p <0.001 for heterogeneity). A linear dose–response association between serum 25(OH)D concentrations and incident depression was observed (p = 0.96 for nonlinearity). Conclusion Serum 25(OH)D concentration is negatively associated with the risk of depression in older adults. This meta-analysis suggests that increasing 25(OH)D levels may be a useful approach to reduce the risk of depression in older adults and highlights the need for further large-scale clinical studies.
KeywordSerum 25-hydroxyvitamin d Depression Dose–response Meta-analysis
DOI10.1016/j.jagp.2019.05.022
Indexed BySCI
Language英语
WOS Research AreaGeriatrics & Gerontology ; Psychiatry
WOS SubjectGeriatrics & Gerontology ; Gerontology ; Psychiatry
WOS IDWOS:000488523100005
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China
2.Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China
3.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
4.University of Notre Dame Australia, Fremantle, Australia
5.Division of Psychiatry, Medical School, University of Western Australia, Perth, Australia
6.Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia
7.Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, Australia
8.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
Recommended Citation
GB/T 7714
Haibin Li Ph.D.,Dianqin Sun B.S.,Anxin Wang Ph.D.,et al. Serum 25-Hydroxyvitamin D Levels and Depression in Older Adults: A Dose–Response Meta-Analysis of Prospective Cohort Studies[J]. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY,2019,27(11):1192-1202.
APA Haibin Li Ph.D..,Dianqin Sun B.S..,Anxin Wang Ph.D..,Huiying Pan B.S..,Wei Feng M.S..,...&Xiuhua Guo Ph.D..(2019).Serum 25-Hydroxyvitamin D Levels and Depression in Older Adults: A Dose–Response Meta-Analysis of Prospective Cohort Studies.AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY,27(11),1192-1202.
MLA Haibin Li Ph.D.,et al."Serum 25-Hydroxyvitamin D Levels and Depression in Older Adults: A Dose–Response Meta-Analysis of Prospective Cohort Studies".AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 27.11(2019):1192-1202.
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