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Reactive versus Constitutive: Reconcile the Controversial Results about the Prognostic Value of PD-L1 Expression in cancerA
Dapeng Hao1,2; Guangyu Wang3; Weiwei Yang1; Jinan Gong1; Xingmin Li4; Mingming Xiao5; Lijie He6; Li Wang2; Xiaobo Li1; Lijun Di2
2019-07-21
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume15Issue:9Pages:1933-1941
AbstractThe prognostic value of programmed death-ligand 1 (PD-L1) has been controversial in recent studies. PD-L1 is known to play a major role in suppressing the immune response, yet increasing studies have reported that PD-L1 expression has a favorable prognostic value for cancer patients. This raises the concern about how to understand PD-L1 expression: merely an immune inhibitory signal, or more likely a reactive process to T-cell response that indicates cytotoxic T lymphocyte (CTL) level in a tumor? To solve this dilemma, an integrative investigation is required. We compared the PD-L1 expression between tumor cells and immune cells, and characterized the inter- and intra-tumor correlation between CTL and PD-L1 expression. The prognostic values between PD-L1 and CTL is compared across 15 solid cancers and 11 independent cohorts of ovarian cancer. PD-L1 and PD-L1-adjusted CTL are analyzed in immunotherapy dataset receiving nivolumab. We observed unexpected high concordance between the prognostic value of PD-L1 and CTL across different cancers and cohorts. We found primarily reactive rather than constitutive PD-L1 expression in most tumors. We revealed that PD-L1-adjusted CTL level, rather than the expression of PD-L1, effectively predicts the responders to immune checkpoint inhibitors. This study highlights the importance of PD-L1 expression, as primarily a signature of reacting efficiency of pre-existing anti-tumor immunity, in balancing the tumor microenvironment. Importantly, it suggests that the reactive efficiency of PD-L1 is more useful to predict the response to immunotherapy.
KeywordPd-l1 Ctl Cancer Immunotherapy Microenvironment
DOI10.7150/ijbs.33297
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000481578100013
PublisherIVYSPRING INT PUBL, PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXiaobo Li; Lijun Di
Affiliation1.Department of Pathology, Harbin Medical University, Harbin, China
2.Faculty of Health Sciences, University of Macau, Macau, China
3.Department of Gastrointestinal Medical Oncology, the Affiliated Tumor Hospital of Harbin Medical University, Harbin, China
4.Shuwen Biotech Co. Ltd., Deqing, China
5.Department of Pathology, People's Hospital of Liaoning Province. Shenyang, China
6.Department of Medical Oncology, People's Hospital of Liaoning Province. Shenyang, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Dapeng Hao,Guangyu Wang,Weiwei Yang,et al. Reactive versus Constitutive: Reconcile the Controversial Results about the Prognostic Value of PD-L1 Expression in cancerA[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(9):1933-1941.
APA Dapeng Hao.,Guangyu Wang.,Weiwei Yang.,Jinan Gong.,Xingmin Li.,...&Lijun Di.(2019).Reactive versus Constitutive: Reconcile the Controversial Results about the Prognostic Value of PD-L1 Expression in cancerA.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(9),1933-1941.
MLA Dapeng Hao,et al."Reactive versus Constitutive: Reconcile the Controversial Results about the Prognostic Value of PD-L1 Expression in cancerA".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.9(2019):1933-1941.
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