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A BODIPY-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long-Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features
Lei Chen1; Dandan Chen2; Yifei Jiang1; Jicheng Zhang1; Jiangbo Yu1; Christopher C. DuFort3; Sunil R.4,5,6; Xuanjun Zhang7; Changfeng Wu2; Daniel T. Chiu1
2019-05-20
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume58Issue:21Pages:7008-7012
Abstract

Bright long‐wavelength‐excitable semiconducting polymer dots (LWE‐Pdots) are highly desirable for in vivo imaging and multiplexed in vitro bioassays. LWE‐Pdots have been obtained by incorporating a near‐infrared (NIR) emitter into the backbone of a polymer host to develop a binary donor–acceptor (D–A) system. However, they usually suffer from severe concentration quenching and a trade‐off between fluorescence quantum yield (Φf) and absorption cross‐section (σ). Herein, we describe a ternary component (D1/D2–A) strategy to achieve ultrabright, green laser‐excitable Pdots with narrow‐band NIR emission by introducing a BODIPY‐based assistant polymer donor as D1. The D1/D2–A Pdots possess improved Φf and σ compared to corresponding binary D2–A Pdots. Their Φf is as high as 40.2 %, one of the most efficient NIR Pdots reported. The D1/D2–A Pdots show ultrahigh single‐particle brightness, 83‐fold brighter than Qdot 705 when excited by a 532 nm laser. When injected into mice, higher contrast in vivo tumor imaging was achieved using the ternary Pdots versus the binary D–A Pdots.

KeywordBodipy Invivo Imaging Narrow-band Absorption Near-infrared Emission Semiconducting Polymer Dots
DOI10.1002/anie.201902077
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000476423300030
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChangfeng Wu; Daniel T. Chiu
Affiliation1.Department of Chemistry, University of Washington, Seattle, WA, 98195 USA
2.epartment of Biomedical Engineering, Southern University Science and Technology, Shenzhen, Guangdong, 510855 China
3.Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109 USA
4.HingoraniClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109 USA
5.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109 USA
6.Department of Medicine, University of Washington, Seattle, WA, 98195 USA
7.Faculty of Health Sciences, University of Macau, Macau SAR, 999078 China
Recommended Citation
GB/T 7714
Lei Chen,Dandan Chen,Yifei Jiang,et al. A BODIPY-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long-Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(21):7008-7012.
APA Lei Chen.,Dandan Chen.,Yifei Jiang.,Jicheng Zhang.,Jiangbo Yu.,...&Daniel T. Chiu.(2019).A BODIPY-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long-Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(21),7008-7012.
MLA Lei Chen,et al."A BODIPY-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long-Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.21(2019):7008-7012.
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