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Activatable Small-Molecule Photoacoustic Probes that Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer's Disease
Shichao Wang1; Zonghai Sheng2; Zhenguo Yang3; Dehong Hu2; Xiaojing Long2; Gang Feng1; Yubin Liu1; Zhen Yuan1; Jingjing Zhang3; Hairong Zheng2; Xuanjun Zhang1
2019-09
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume58Issue:36Pages:12415-12419
Abstract

Copper enrichment in the brain is highly related to Alzheimer's disease (AD) pathogenesis, but in vivo tracing of Cu2+ in the brain by imaging techniques is still a great challenge. In this work, we developed a series of activatable photoacoustic (PA) probes with low molecular weights (less than 438 Da), RPS1–RPS4, which can specifically chelate with Cu2+ to form radicals with turn‐on PA signals in the near‐infrared (NIR) region. Introducing the electron‐donating group N,N‐dimethylaniline into the probe was found to significantly enhance the radical stability and PA intensity. The best probe in the series, RPS1, showed a fast response (within seconds) to Cu2+ with high selectivity and a low PA detection limit of 90.9 nm. Owing to the low molecular weight and amphiphilic structure, RPS1 could effectively cross the blood–brain barrier (BBB) and thus allowed us, for the first time, to visualize Cu2+ in vivo via PA imaging in the brains of AD mice.

KeywordAlzheimer's Disease Biosensors Blood-brain Barrier Copper Photoacoustic Probe
DOI10.1002/anie.201904047
Indexed BySCIE ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000479165900001
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXuanjun Zhang
Affiliation1.Cancer Centre and Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau SAR, P. R. China
2.Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055 P. R. China
3.Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001 P. R. China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Shichao Wang,Zonghai Sheng,Zhenguo Yang,et al. Activatable Small-Molecule Photoacoustic Probes that Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer's Disease[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(36):12415-12419.
APA Shichao Wang.,Zonghai Sheng.,Zhenguo Yang.,Dehong Hu.,Xiaojing Long.,...&Xuanjun Zhang.(2019).Activatable Small-Molecule Photoacoustic Probes that Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer's Disease.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(36),12415-12419.
MLA Shichao Wang,et al."Activatable Small-Molecule Photoacoustic Probes that Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer's Disease".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.36(2019):12415-12419.
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