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Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria
Yubin Liu; Lei Fu; Mengze Xu; Jun Zheng; Zhen Yuan
2019-01-10
Source PublicationSENSORS
ISSN1424-8220
Volume19Issue:2
Abstract

In this study, dual-modal fluorescence and photoacoustic microscopy was performed for noninvasive and functional in vivo imaging of inflammation induced by green fluorescent protein (GFP) transfected bacteria in mice ear. Our imaging results demonstrated that the multimodal imaging technique is able to monitor the tissue immunovascular responses to infections with molecular specificity. Our study also indicated that the combination of photoacoustic and fluorescence microscopy imaging can simultaneously track the biochemical changes including the bacterial distribution and morphological change of blood vessels in the biological tissues with high resolution and enhanced sensitivity. Consequently, the developed method paves a new avenue for improving the understanding of the pathology mechanism of inflammation.

KeywordGfp-expressing Bacteria Biosensor Inflammation/infection Fluorescence Imaging Photoacoustic Microscopy
DOI10.3390/s19020238
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Engineering ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Engineering, Electrical & Electronic ; Instruments & Instrumentation
WOS IDWOS:000458569300021
PublisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
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Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF COLLABORATIVE INNOVATION
Faculty of Health Sciences
Corresponding AuthorZhen Yuan
AffiliationCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yubin Liu,Lei Fu,Mengze Xu,et al. Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria[J]. SENSORS,2019,19(2).
APA Yubin Liu,Lei Fu,Mengze Xu,Jun Zheng,&Zhen Yuan.(2019).Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria.SENSORS,19(2).
MLA Yubin Liu,et al."Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria".SENSORS 19.2(2019).
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