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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Chuxia Deng1,2; Pumin Zhang3; J.Wade Harper3; Stephen J.Elledge1,3,4; Philip Leder1,2
1995-08
Source PublicationCELL
ISSN0092-8674
Volume82Issue:4Pages:675-684
Abstractp21CIP11WAF1 is a CDK Inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from this relationship. To test these notions, we created mice lacking p21CIP1/WAF1. They develop normally and (unlike p53−/− mice) have not developed spontaneous malignancies during 7 months of observation. Nonetheless, p21−/− embryonic fibroblasts are significantly deficient in their ability to arrest in G1 In response to DNA damage and nucleotide pool perturbation. p21−/− cells also exhibit a significant growth alteration in vitro, achieving a saturation density as high as that observed In p53−/− cells. In contrast, other aspects of p53 function, such as thymocytic apoptosis and the mitotic spindle checkpoint, appear normal. These results establish the role of p21CIP1/WAF1 in the G1 checkpoint, but suggest that the antiapoptotic and the anti-oncogenic effects of p53 are more complex.
DOI10.1016/0092-8674(95)90039-X
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:A1995RR73400018
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Cited Times [WOS]:1843   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionPersonal research not belonging to the institution
Faculty of Health Sciences
Affiliation1.Howard Hughes Medical Institute Harvard Medical School Boston, Massachusetts 02115, USA
2.Department of Genetics Harvard Medical School Boston, Massachusetts 02115, USA
3.Vern and Marrs McLean Department of Biochemistry Baylor College of Medicine Houston, Texas 77030, USA
4.Department of Human and Molecular Genetics Baylor College of Medicine Houston, Texas 77030, USA
Recommended Citation
GB/T 7714
Chuxia Deng,Pumin Zhang,J.Wade Harper,et al. Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control[J]. CELL,1995,82(4):675-684.
APA Chuxia Deng,Pumin Zhang,J.Wade Harper,Stephen J.Elledge,&Philip Leder.(1995).Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.CELL,82(4),675-684.
MLA Chuxia Deng,et al."Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control".CELL 82.4(1995):675-684.
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