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FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
Qingyu Zhang1; Shan Yu1; Samson Ian Sam Lok1; Alice Sze Tsai Wong2; Yufei Jiao3; Leo Tsz On Lee1
2019-07
Source PublicationJOURNAL OF CELLULAR AND MOLECULAR MEDICINE
ISSN1582-4934
Volume23Issue:7Pages:4569-4581
AbstractAlthough invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments. We compared the molecular signature of IOC and LMP cases by analysing their transcriptomic data and re-clustered them according to these data rather than the pathological dissection. We identified that FAM83D was highly expressed in IOC. To verify the role of FAM83D in the progression and metastasis, we used the isogenic ovarian cancer metastatic models, highly metastatic cells (HM) and non-metastatic cells (NM). Overexpression of FAM83D significantly promoted cell proliferation, migration and spheroid formation. This was consistent with previous data showing that high FAM83D expression is associated with poor prognosis in cancer patients. Moreover, similar to the HM cells, the FAM83D-overexpressing NM cells demonstrated stronger phosphorylation of the epidermal growth factor receptor (EGFR) and c-Raf. This indicates that the action of FAM83D is mediated by the activation of the EGFR pathway. Taken together, this report suggested that FAM83D might be an excellent molecular marker to discriminate between IOC and LMP.
KeywordFam83d Nvasive Epithelial Ovarian Cancer, Low Malignant Potential Ovarian Tumour Molecular Diagnosis
DOI10.1111/jcmm.14360
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Research & Experimental Medicine
WOS SubjectCell Biology ; Medicine, Research & Experimental
WOS IDWOS:000473010500008
PublisherWILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLeo Tsz On Lee
Affiliation1.Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau, China
2.School of Biological Sciences, The University of Hong Kong, Hong Kong, China
3.Department of Pathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Qingyu Zhang,Shan Yu,Samson Ian Sam Lok,et al. FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2019,23(7):4569-4581.
APA Qingyu Zhang,Shan Yu,Samson Ian Sam Lok,Alice Sze Tsai Wong,Yufei Jiao,&Leo Tsz On Lee.(2019).FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,23(7),4569-4581.
MLA Qingyu Zhang,et al."FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 23.7(2019):4569-4581.
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