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Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome Editing
Jie Liu1,2; Guangyu Zhou1,2; Li Zhang3; Qi Zhao1,2
2019-03-19
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume10
Abstract

Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of hematological and solid malignancies. However, despite the success of this field, there remain some major challenges, including accelerated T cell exhaustion, potential toxicities, and insertional oncogenesis. To overcome these limitations, recent advances in CRISPR technology have enabled targetable interventions of endogenous genes in human CAR T cells. These CRISPR genome editing approaches have unleashed the therapeutic potential of CAR T cell therapy. Here, we summarize the potential benefits, safety concerns, and difficulties in the generation of gene-edited CAR T cells using CRISPR technology.

KeywordChimeric Antigen Receptor Crispr Gene Editing Immunotherapy Cancer Car t
DOI10.3389/fimmu.2019.00456
Indexed BySCIE
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000461591200001
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Cancer Centre, Faculty of Health Sciences, University of Macau, Macau, China
2.Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
3.Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Jie Liu,Guangyu Zhou,Li Zhang,et al. Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome Editing[J]. FRONTIERS IN IMMUNOLOGY,2019,10.
APA Jie Liu,Guangyu Zhou,Li Zhang,&Qi Zhao.(2019).Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome Editing.FRONTIERS IN IMMUNOLOGY,10.
MLA Jie Liu,et al."Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome Editing".FRONTIERS IN IMMUNOLOGY 10(2019).
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