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A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy
Zhimei He1; Xiaolin Huang2; Chen Wang3; Xiangli Li1; Yijing Liu4; Yijing Liu4; Zijian Zhou4; Sheng Wang4; Fuwu Zhang4; Zhantong Wang4; Orit Jacobson4; Jun‐Jie Zhu1; Guocan Yu4; Yunlu Dai5; Xiaoyuan Chen4
2019-06-24
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume58Issue:26Pages:8752-8756
Abstract

Tumor hypoxia, the "Achilles'  heel" of current cancer therapies, is indispensable to drug resistance and poor therapeutic outcomes especially for radiotherapy. Here we propose an in situ catalytic oxygenation strategy in tumor using porphyrinic metal-organic framework (MOF)-gold nanoparticles (AuNPs) nanohybrid as a therapeutic platform to achieve O2-evolving chemoradiotherapy. The AuNPs decorated on the surface of MOF effectively stabilize the nanocomposite and serve as radiosensitizers, whereas the MOF scaffold acts as a container to encapsulate chemotherapeutic drug doxorubicin. In vitro and in vivo studies verify that the catalase-like nanohybrid significantly enhances the radiotherapy effect, alleviating tumor hypoxia and achieving synergistic anticancer efficacy. This hybrid nanomaterial remarkably suppresses the tumor growth with minimized systemic toxicity, opening new horizons for the next generation of theranostic nanomedicines.

DOI10.1002/anie.201902612
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000474806700020
PublisherWILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorJun‐Jie Zhu; Guocan Yu; Yunlu Dai; Xiaoyuan Chen
Affiliation1.State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 (P. R. China)
2.State Key Laboratory of Food Science and Technology School of Food Science and Technology, Nanchang University Nanchang 330047 (P. R. China)
3.State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences, Nanjing University Nanjing 210093 (P. R. China)
4.Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
5.Faculty of Health Sciences, University of Macau Macau SAR 999078 (P. R. China)
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zhimei He,Xiaolin Huang,Chen Wang,et al. A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(26):8752-8756.
APA Zhimei He.,Xiaolin Huang.,Chen Wang.,Xiangli Li.,Yijing Liu.,...&Xiaoyuan Chen.(2019).A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(26),8752-8756.
MLA Zhimei He,et al."A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.26(2019):8752-8756.
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