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Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy
Zhan Zhang1,2; Wei Sang1,2; Lisi Xie1,2; Yunlu Dai1,2
2019-08-21
Source PublicationCOORDINATION CHEMISTRY REVIEWS
ISSN0010-8545
Volume399
Abstract

Metal-organic frameworks (MOFs) are a novel class of porous materials made from metal ions and organic ligands, and have been widely explored as multifunctional nanoplatforms. MOFs present unique physicochemical characteristics, such as large surface area, tunable size and structure, and easy modification, thereby making them promising candidates for drug delivery, biomedical imaging, and therapeutic applications. Simultaneous utilization of organic linkers and various metal ions as the coordination centers provides possibility to generate multifunctional MOFs with a number of advantages. This feature article summarizes the development and modification of MOFs with emphasis on the recent progress of chemotherapy-based synergistic combination therapy and bioimaging techinques, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and optical imaging (OI). Future prospects and challenges of MOFs in the research of translational medicine are also discussed. 

(c)2019 Elsevier B.V. All rights reserved.

KeywordMetal-organic Frameworks Surface Modification Bioimaging Cancer Chemotherapy Synergistic Therapy
DOI10.1016/j.ccr.2019.213022
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000487567900004
PublisherELSEVIER SCIENCE SA, PO BOX 564, 1001 LAUSANNE, SWITZERLAND
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYunlu Dai
Affiliation1.Cancer Center, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
2.Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zhan Zhang,Wei Sang,Lisi Xie,et al. Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy[J]. COORDINATION CHEMISTRY REVIEWS,2019,399.
APA Zhan Zhang,Wei Sang,Lisi Xie,&Yunlu Dai.(2019).Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy.COORDINATION CHEMISTRY REVIEWS,399.
MLA Zhan Zhang,et al."Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy".COORDINATION CHEMISTRY REVIEWS 399(2019).
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