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Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma
Lijia Luo1,2; Muhammad Zubair Iqbal1; Chuang Liu1,2; Jie Xing1; Ozioma Udochukwu Akakuru1,2; Qianlan Fang1,2; Zihou Li1; Yunlu Dai3; Aiguo Li4; Yong Guan5; Aiguo Wu1
2019-09-03
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume223
Abstract

Malignant melanoma, one of the most aggressive types of cancer easily metastasizes, making it extremely difficult to treat and unresponsive to current therapies. Recent breakthroughs in nanomaterials-based cancer immunotherapy have provided potential specific strategy for tumor and metastasis inhibition. With the development of nanotechnology, inorganic nanomaterials have been increasingly studied for their potential cancer therapeutic and molecular imaging functions. However, only iron-based nanomaterials have been approved by the Food and Drug Administration (FDA) in inorganic nanomedicines. For promising clinical application, a new type of nanocomposite is engineered by combining ultra-small iron oxide nanoparticles (Fe3O4 NPs) and ovalbumin (OVA), denoted as Fe3O4-OVA nanocomposites in this study. Interestingly, this is the first time that Fe3O4 NPs are found as nano-immunopotentiators helping nanocomposites efficiently stimulate dendritic cell-based immunotherapy and potentially-activate macrophages. These nanocomposites efficiently stimulate the maturation level of bone marrow derived dendritic cell (BMDCs) and corresponding activation of T cells and also potentially-activate macrophages. With the help of the Fe3O4 nano-immunopotentiators (Fe3O4 NPs), this therapeutic and prophylactic Fe3O4-OVA vaccine can not only efficiently inhibit the subcutaneous and metastatic B16-OVA tumor growth but also successfully prevent the formation of subcutaneous and metastatic tumor, providing a promising strategy for expanding the clinical use of Fe-based nanomaterials.

KeywordCancer Immunotherapy Nanomaterials Prophylactic Vaccines Metastasis Dendritic Cells
DOI10.1016/j.biomaterials.2019.119464
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000491303800015
PublisherELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
The Source to ArticleBIOMATERIALS
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorAiguo Wu
Affiliation1.Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
2.Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China
3.Faculty of Health Sciences, University of Macau, Macau SAR, 999078, PR China
4.Shanghai Synchrotron Radiation Facility, Chinese Academy of Sciences, Shanghai, 201204, PR China
5.National Synchrotron Radiation Laboratory in Hefei, University of Science & Technology of China, Hefei, 230026, PR China
Recommended Citation
GB/T 7714
Lijia Luo,Muhammad Zubair Iqbal,Chuang Liu,et al. Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma[J]. BIOMATERIALS,2019,223.
APA Lijia Luo.,Muhammad Zubair Iqbal.,Chuang Liu.,Jie Xing.,Ozioma Udochukwu Akakuru.,...&Aiguo Wu.(2019).Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma.BIOMATERIALS,223.
MLA Lijia Luo,et al."Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma".BIOMATERIALS 223(2019).
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