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Iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent
Chung Hang Leung; Hai Jing Zhong; Dik Lung Ma; Hui Min Wang
Rights HolderKAOHSIUNG MEDICAL UNIVERSITY ; HONG KONG BAPTIST UNIVERSITY ; UNIVERSITY OF MACAU
Date Available2017-12-12
CountryUnited States
Subtype发明专利
Contribution Rank1
Abstract

Bromodomain-containing protein 4 (BRI)) has recently emerged as an attractive epigenetic target for anticancer therapy. Iridium(III) complexes are useful as irreversible inhibitor of BRD4. Complex 1a of the formula : is particularly useful.

Application Date2017-07-27
Patent NumberUS9840526B1
Language英语
Application NumberUS15661288
Open (Notice) NumberUS9840526B1
Fulltext Access
Document TypePatent
CollectionInstitute of Chinese Medical Sciences
AffiliationUniversity of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Chung Hang Leung,Hai Jing Zhong,Dik Lung Ma,et al. Iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent. US9840526B1.
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