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Supramolecular Encapsulation of Vitamin B6by Macrocyclic Nanocontainer Cucurbit[7]uril
Wanying Li1; Shengke Li1; an W. Wyman2; Donal H. Macartney2; Qingwen Zhang1; Ying Zheng1; Ruibing Wang1
2015
Source PublicationJOURNAL OF NANOMATERIALS
ISSN1687-4110
Abstract

A pharmaceutically and biologically relevant molecule, pyridoxine hydrochloride (vitamin B-6), was encapsulated inside the cavity of a molecular container, cucurbit[7]uril (CB[7]), in aqueous solution. The CB[7] based "nanocapsule" of vitamin B-6 has been investigated for the first time, via H-1 NMR and UV-visible spectroscopic titrations (including Job's plot) and ab initio molecular modeling. The results have demonstrated that vitamin B-6 forms stable host-guest complexes within CB[7] in 1 : 1 stoichiometry, with a binding affinity of (4.0 +/- 0.5) x 10(3) M-1. Such a nanocapsule could potentially find application in vitamin B-6 formulation for the purpose of enhancing the stability, absorption, and delivery of this important vitamin.

DOI10.1155/2015/574013
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000365535600001
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,Taipa, Macau, China
2.Department of Chemistry, Queen’s University, Kingston, ON, Canada K7L 3N6
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wanying Li,Shengke Li,an W. Wyman,et al. Supramolecular Encapsulation of Vitamin B6by Macrocyclic Nanocontainer Cucurbit[7]uril[J]. JOURNAL OF NANOMATERIALS,2015.
APA Wanying Li.,Shengke Li.,an W. Wyman.,Donal H. Macartney.,Qingwen Zhang.,...&Ruibing Wang.(2015).Supramolecular Encapsulation of Vitamin B6by Macrocyclic Nanocontainer Cucurbit[7]uril.JOURNAL OF NANOMATERIALS.
MLA Wanying Li,et al."Supramolecular Encapsulation of Vitamin B6by Macrocyclic Nanocontainer Cucurbit[7]uril".JOURNAL OF NANOMATERIALS (2015).
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